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Hepatoprotective Activity of Dandelion (Taraxacum officinale) Water Extract against D-Galactosamine-Induced Hepatitis in Rats

D-Galactosamine으로 유발된 간손상에 대한 민들레 열수추출물의 예방효과

  • Park, Ji-Young (School of Food and Life Science, Food Science Institute, Biohealth Products Research Center, Inje University) ;
  • Park, Chung-Mu (School of Food and Life Science, Food Science Institute, Biohealth Products Research Center, Inje University) ;
  • Kim, Jin-Ju (School of Food and Life Science, Food Science Institute, Biohealth Products Research Center, Inje University) ;
  • Song, Young-Sun (School of Food and Life Science, Food Science Institute, Biohealth Products Research Center, Inje University)
  • 박지영 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 박충무 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 김진주 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터) ;
  • 송영선 (인제대학교 의생명공학대학 식품생명과학부, 식품과학연구소 및 바이오헬스 소재 연구센터)
  • Published : 2008.02.29

Abstract

This study aimed to investigate the protective effect of dandelion water extract (DWE) on liver injury induced by D-galactosamine (GalN) in Sprague-Dawley rats. Fifty rats were divided into 5 groups; normal control (C), DWE-control (DWE-C: saline injection after feeding 3% DWE diet), GalN-control (GalN-C: GalN injection after normal diet), DWE I (GalN injection after feeding 1.5% DWE diet), and DWE II (GalN injection after feeding 3% DWE diet). After 2 weeks, the acute hepatitis was induced by GalN (650 mg/kg, i.p.) and 24 hrs later, all rats were sacrificed. The DWE supplement ameliorated the serum alanine and aspartate aminotransferase (AST, ALT) as well as alkaline phosphatase (ALP) and tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$. Hepatic antioxidative enzyme activities, such as catalase, GSH peroxidase, GSH reductase, and Mn-superoxide dismutase (SOD) were slightly or significantly elevated by the treatment of DWE. Moreover, the histological examination corresponded with these biochemical observations. According to these findings, dandelion could be used as a potential therapeutic material for treating chemically induced acute hepatitis.

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