Effects of Samhwang-tang(Sanhuang-tang) on Obese Rats Induced by High Fat Diet, MSG and Ovariectomy

삼황탕(三黃湯)이 고지방식이, MSG 및 난소적출로 유발된 흰쥐의 비만에 미치는 영향

  • Min, Hong-Gyu (Dept. of Anatomy, College of Oriental Medicine, Kyung-Hee Univeristy) ;
  • Sohn, Young-Joo (Dept. of Gynecology, College of Oriental Medicine, Sang-Ji University) ;
  • Shim, Eun-Shep (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung-Hee University) ;
  • Kim, Bum-Hoi (Dept. of Anatomy, College of Oriental Medicine, Kyung-Hee Univeristy) ;
  • Jung, Hyuk-Sang (Dept. of Anatomy, College of Oriental Medicine, Kyung-Hee Univeristy) ;
  • Sohn, Nak-Won (Dept. of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung-Hee University)
  • 민홍규 (경희대학교 한의과대학 해부학교실) ;
  • 손영주 (상지대학교 한의과대학 부인과교실) ;
  • 심은섭 (경희대학교 동서의학대학원 신경과학및뇌질환전공) ;
  • 김범회 (경희대학교 한의과대학 해부학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학및뇌질환전공)
  • Received : 2007.09.18
  • Accepted : 2008.01.08
  • Published : 2008.01.31
  • 30 1


Abstract

Objectives : Obesity is a metabolic disease resulted from various causes including nutritional disproportion, hormonal imbalance, and hypothalamic nuclei disorder. Samhwang-tang(Sanhuang-tang, SHT) is composed of 5 herbs (Ephedrae Herba, Scutellariae Radix, Typhae pollen, Acori Rhizoma and Ansu Semen) and is frequently used for obese patients. This study investigated anti-obesity effects of SHT on the rats. Methods : Obesity was induced by high fat diet (HFD), monosodium L-glutamate injection (MSG) and ovariectomy (OVX) in the Sprague-Dawley rats. Water extract of SHT was treated for 2 weeks, then changes of body weight gain and epididymal fat cell size were measured. In OVX animals, c-Fos and neuropeptide Y (NPY) expressions in hypothalamic nuclei were observed with immunohistochemistry. Results : SHT treatment demonstrated significant decrease of body weight gain in obesity induced by HFD and OVX, but not in obesity induced by MSG. SHT treatment demonstrated significant decrease of fat cell size in obesity induced by HFD, but not in obesity induced by MSG. On c-Fos and NPY expressions in hypothalamic nuclei, SHT treatment resulted significant decrease of immuno-reactivity of c-Fos and NPY in obesity induced by OVX. Conclusions : These results suggest that SHT has a weight loss effect against obesity induced by nutritional disproportion of diet intake and hormonal imbalance, especially without central nervous system disorder.