Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)
- Volume 18 Issue 4
- /
- Pages.13-24
- /
- 2008
- /
- 1229-1854(pISSN)
- /
- 2288-4114(eISSN)
Effect of Poncirus Trifoliata on Colonic Motility in Spinal Cord Injured Rats
척수손상 흰쥐에서 대장 운동에 대한 지실의 효과
- Choi, Chul-Won (Sung Shim Oriental Medicine Clinic) ;
- Joo, Min-Cheol (Dept. of Rehabilitation Medicine, Won-Kwang University School of Medicine) ;
- Lee, Moon-Young (Dept. of Physiology, Institute of Won-Kwang Medical Science & Digestive Disease Research Institute)
- 최철원 (성심 한의원) ;
- 주민철 (원광대학교 의과대학 재활의학과교실) ;
- 이문영 (원광대학교 의과대학 생리학교실.원광의과학연구소 및 소화기질환연구소)
- Received : 2008.09.17
- Accepted : 2008.10.20
- Published : 2008.10.31
Abstract
Objectives : The purpose of this study was to investigate the effect of Poncirus Trifoliata(PT) on improvement of fecal impaction in spinal cord injured(SCI) rats. Methods : Fifteen adult Sprague-Dawley female rats were used weighing 200~250 g. A complete spinal cord transection was performed surgically at the T10 cord level. Experimental groups were assigned into 3 groups: Control(n=5), SCI+vehicle(n=5) and SCI+PT(n=5). PT was administered 100mg/kg in 0.5ml every 24 hours from 1st operation day to 7th day. We measured the body weight and food intake as well as the number and the weight of fecal pellet every morning. After 1 week of operation, whole colon was divided into proximal and distal segments under anesthesia. Each segment of colon was mounted with longitudinal direction in a organ bath. We measured spontaneous contraction and compared the area under the curve in each segments. Enhanced responses were observed by acetylcholine(
Acknowledgement
Supported by : 원광대학교