Novel circulatory connection from the acupoint Zhong Wan(CV12) to pancreas

중완혈에서 췌장으로 이어지는 새로운 순환적 연결

  • Kim, Min-Soo (Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University) ;
  • Sung, Baeck-Kyoung (Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University) ;
  • Ogay, Vyacheslav (Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University) ;
  • Choi, Chun-Ju (Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University) ;
  • Kim, Min-Su (Department of Large/Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida) ;
  • Kang, Dae-In ;
  • Soh, Kwang-Sup (Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University)
  • 김민수 (서울대학교 물리천문학부 한의학물리연구실) ;
  • 성백경 (서울대학교 물리천문학부 한의학물리연구실) ;
  • ;
  • 최천주 (서울대학교 물리천문학부 한의학물리연구실) ;
  • 김민수 (플로리다대학교 수의과대학 대/소동물 임상과학과) ;
  • 강대인 (대한약침학회) ;
  • 소광섭 (서울대학교 물리천문학부 한의학물리연구실)
  • Published : 2008.03.31


Objectives : Demonstrating a novel circulatory path from the acupoint(CV12) to the pancreas. Method : Alcian blue(1% solution, $20{\mu}l$, pH 7.4) was injected into the acupoint(CV12). Two hours later the surfaces of internal organs were observed by using a stereomicroscope. Results : Alcian blue arrived and colored the omental fat band(OFB) on the pancreas. The OFB connected the head and tail of the pancreas, the pancreas and the spleen, and the pancreas and the stomach. Conclusion : The existence of a novel circulatory path from the acupoint CV12 to the pancreas and its OFB was demonstrated.


  1. Yan JG(ed), Anatomical atlas of acupoints. Shanghai : Shanghai Scientific Publishers : 161
  2. Lin JG, Chang SL and Cheng JT. Release of - endorphin from adrenal gland to lower plasma glucose by the electroacupuncture at Zhongwan acupoint in rats. Neurosci. Lett. 2002 ; 326: 17-20
  3. Recklinghausen F von. Uber eiter und bindegewebsk Virchows Arch. A Pathol. Anat. Histopathol 1863 ; 28 : 157-197
  4. Ranvier L. Du developpement et de l'accroisse lments des vaisseaux sanguins. Arch.Phys. Norm. Pathol. 1874 ; 6 : 429-446
  5. Beelen RHJ. The greater omentum: Physiology and immunological concepts. Neth. J. Surg. 1991 ; 43 :145-150
  6. Dux K, Rouse RV and Kyewski B. Composition of the lymphoid cell population from omental milky spots during the immune response in C57BL/Ka mice. Eur. J. Immunol. 1986 ; 16 : 1029-1032
  7. Takemori N and Ito T. Uptake of horseradish peroxidase(HRP) in omental milk spot cells of the mouse: an electron microscope study. Hokkaido Igaku Zasshi 1980 ; 55 : 409-418
  8. Hirai K, Takemori N and Namiki M. Erythropoiesis in mouse omental milky spots induced by erythropoietin: light and electron microscopic study. Int. J. Exp. Pathol. 1994 ; 75 : 375-383
  9. Krist LFG, Brouwer JJE, Estermans IL, Cuesta MA, Meijer S and Beelen RHJ. Cellular composition of human milky spots. Anat. Rec. 1995 ; 241 :163-174
  10. Krist LFG., Koenen H, Calame W, van der Harten JJ, van der Linden JC, Eestermans IL, Meyer S and Beelen RHJ. Ontogeny of milky spots in the human greater omentum: An immunochemical study. Anat. Rec. 1997 ; 249 : 399-404<399::AID-AR11>3.0.CO;2-J
  11. Takemori N and Ito T. Response of omental milk spots to colloidal saccharated ferric oxide in the mouse: light and electron microscopic study. Hokkaido Igaku Zasshi 1981 ; 56 : 199-216
  12. Kasnitz P, Grant L, Napoliello M and Nathan C. The use of alcian blue in vivo. I. Physiologic considerations. Histochemie 1967 ; 10 : 107-114
  13. Parsons DA and Mcmanvs JFA. Glomerular localization of intravenous Alcian blue. Anat. Rec. 1964 ; 149 : 605-608
  14. Bailie MD and Mcmanus JFA. Experiments with Alcian blue in vivo. I. Subcutaneous injections in rats. Lab. Invest. 1963 ; 12 : 611-615
  15. Chang SL, Lin JG, Chi TC, Liu IM and Cheng JT. An insulin-dependent hypoglycemia induced by electroacupuncture at the Zhongwan(CV12) acupoint in diabetic rats. Diabetologia 1999 ; 42 : 250-255
  16. Shimotsuma M, Takahashi T, Kawata M and Dux K. Cellular subsets of the milky spots in the human greater omentum. Cell. Tissue Res. 1991 ; 264 : 599-601
  17. van Vugt E, van Rijthoven EAM, Kamperdijk EWA and Beelen RHJ. Omental milky spots in the local immune response in the peritoneal cavity of rats.Anat. Rec. 1996 ; 244 : 235-245<235::AID-AR11>3.0.CO;2-Q
  18. Cranshaw ML and Leak LV. Milky spots of the omentum: a source of peritoneal cells in the normal and stimulated animal. Arch. Histol. Cytol. 1990 ; 53 : 165-177
  19. Kim BH. On the kyungrak system. Pyongyang Med. Sci. Press 1963 ; 10 : 141
  20. Sung B, Kim MS, Lee BC, Yoo JS, Lee SH, Kim YJ, Kim KW and Soh KS. Measurement of flow speed in the channels of novel threadlike structures on the surfaces of mammalian organs. Naturwissenschaften 2007 ; in press

Cited by

  1. Effect of Needling at CV-12 (Zhongwan) on Blood Glucose Levels in Healthy Volunteers: A Pilot Randomized Placebo Controlled Trial vol.9, pp.6, 2016,
  2. Magnetic Resonance Imaging and Acupuncture: A Feasibility Study on the Migration of Tracers after Injection at Acupoints of Small Animals vol.2, pp.2, 2009,
  3. Immediate Effect of Needling at CV-12 (Zhongwan) Acupuncture Point on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus: A Pilot Randomized Placebo-Controlled Trial vol.10, pp.4, 2017,