DOI QR코드

DOI QR Code

The Effect of Sweet Bee Venom Pharmacopuncture(SBVP) on Cancer-Related Pain : A Randomized Controlled Trial and Double Blinded - Pilot study

암성통증에 대한 SBVP 효과 - 무작위대조시험, 이중맹검

  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Kim, Jung-Sun (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
  • 유화승 (대전대학교 둔산한방병원 동서암센터) ;
  • 김정선 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2008.03.31

Abstract

Objectives : To investigate the therapeutic effects of SBVP in the treatment of patients with cancer-related pain. Design : A prospective randomized, double-blind, placebo-controlled study of SBVP. Setting : The study was conducted at the East West Cancer Center of Daejeon University Dunsan Oriental Hospital from March 1, 2007 to June 20, 2007. Patients : 11 patients diagnosed with cancer-related pain of over 3rd degree on the Numeric Rating Scale(NRS)(0, no pain at all, 10, worst pain imaginable) were entered into a double-blind, placebo-controlled trial of SBVP. They were randomized into Groups A and B(SBVP and control group, respectively) using the table of random sampling numbers and never informed of their affiliation by the coordinator. 5 of 6 patients in Group A and 4 of 5 patients in Group B completed the clinical trial. Intervention : SBVP(1ml/day) for group A and Normal Saline Placebo(1ml/day) for group B was injected into the abdomen acupoint, Zhong Wan(CV 12). The treatment was administered daily for five days. Outcome Measures : Degree of cancer-related pain was measured using the Numeric Rating Scale(NRS) before and after each treatment for "Pain right now" and "Average pain in last 24 hours". Statistical Analysis : Analysis regarding variations in NRS was carried out by applying t-tests(independent sample t-test and paired sample t-test) and Wilcoxon signed rank test with level of significance at 5%. Results : Differences in NRS of "Pain right now" for the two groups were statistically significant. The mean improvement point of SBVP was significantly higher than the control group($2.48^{\circ}{\pm}1.52$ vs $0.97^{\circ}{\pm}1.88$, p<0.05). Differences in average pain score before and after treatment in SBVP group were also significant($5.13^{\circ}{\pm}1.77$ vs $2.65^{\circ}{\pm}0.67$, p<0.05) compared with control group. The two groups showed no significant differences for long term effects in "Average pain in last 24 hours." Conclusion : Although further study will be needed on the large scale, SBVP shows potential as an effective treatment for immediate relief of cancer-related pain.

References

  1. Patrick 'L, Ferketich SL, Frame PS. National Institutes of Health State-of-the-Science Conference Statement: Symptom Management in Cancer: Pain, Depression, and Fatigue, July 15-17,2002. J Natl Cancer Inst 2003;95(15):1110-7 https://doi.org/10.1093/jnci/djg014
  2. Ernst E, Cassileth BR. The prevalence of complementary/alternative medicine in cancer a systematic review. Cancer 1998;83:777-82 https://doi.org/10.1002/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O
  3. Thompson JW, Filshie J. Transcutaneous electrical nerve stimulation(TENS) and acupuncture. In: Doyle D, Hanks G, McDonald N, editors. Oxford textbook of palliative medicine. Oxford: Oxford University Press; 1999;421-36
  4. Johnstone PA, Polaton GR, Nlemizow RC, et al. Integration of acupuncture into the oncology clinic. Pallia Med 2002;16;235-9 https://doi.org/10.1191/0269216302pm540oa
  5. Cohen MM: CAM practitioners and 'regular' doctors: Ins integraion possible? Med J Aust 2004;180:645-6
  6. Case Study of cancer patients treated with Herbal Acupuncture Therapy, Journal of KIHA(korean Institute of Herbal Acupuncture) 2004;7:1:27-36 https://doi.org/10.3831/KPI.2004.7.1.027
  7. Effects of Herbal Acupuncture(Soyeum) on cancer patients accompanied by pain, The 2nd Journal of International Congress of KIHA(Korean Institute of Herbal Acupuncture), 2003;6(1):20-7
  8. 대한약침학회. 약침요법 시술지침서. 서울: 한성인쇄. 1999:187-194
  9. 김지훈, 이재동. 슬관절염에 대한 봉독약침의 임상적 고찰. 대한침구학회지. 1999;16(3):26
  10. 왕오호, 안규범, 임진강, 장형석. 퇴행성 슬관절염의 봉독약침 치료효과에 대한 임상적 관찰. 대한침구학회지. 2001;18(3):35-47
  11. 정혜윤, 고형균. 봉독약침액이 염증 및 통증 유전자 발현에 미치는 영향. 대한침구학회지. 2002;19(3):42-49
  12. 이윤섭, 서정철, 이승우 외 1인. 國産蜂毒 및 精製 蜂毒 藥鍼液이 류머티스 關節炎 滑液細胞에 미치는 影響. 대한침구학회지. 2002;19(4): 28-38
  13. 왕오호, 안규범, 임진강, 장형석. 퇴행성 슬관절염의 봉독약침 치료효과에 대한 임상적 관찰. 대한침구학회지. 2001;18(3):35-47
  14. 박재갑, 박찬일, 김노경 외. 종양학. 서울: 일조각. 2003;927
  15. 문동언. 암성통증의 치료. 대한통증학회지.2002;15 (1):5-6
  16. Cohen MM: CAM practitioners and 'regular' doctors: Ins integration possible? Med J Aust 2004;180:645-6
  17. Woollam CH, Jackson AO. Acupuncture in the management of chronic pain. Anaesthesia 1998;53:593-5 https://doi.org/10.1046/j.1365-2044.1998.00364.x
  18. Sellick SM, Zaza C. Critical review of 5 nonpharmacologic strategies for managing cancer pain. Cancer Prev Control 1998;2:7-14
  19. Ernst E, White AR. Acupuncture for back pain: a meta analysis of randomized controlled trials. Arch Intern Med 1998;158:2235-41 https://doi.org/10.1001/archinte.158.20.2235
  20. Ernst E, Pittler MH. The effectiveness of acupuncture in treating acute dental pain: a systematic review. Br Dent J 1998;184:443.7 https://doi.org/10.1038/sj.bdj.4809654
  21. Melchart D, Linde K, Fischer P, White A, Allais G, Vickers A, et al. Acupuncture for recurrent headaches: a systematic review of randomized controlled trials. Cephalalgia 1999;19:779-86 https://doi.org/10.1046/j.1468-2982.1999.1909779.x
  22. 서진우, 박민정, 성인형, 김남옥, 안치권. 급성기 족관절 염좌 환자의 봉약침 시술 효과에 대한 임상적 연구. 대한침구학회지. 2006;23(1):96
  23. 김지훈, 이재동. 슬관절염에 대한 봉독약침의 임상적 고찰. 대한침구학회지. 1999;16(3):26

Cited by

  1. Experimental study of antigenicity test of Sweet Bee Venom in Guinea Pigs vol.14, pp.4, 2011, https://doi.org/10.3831/KPI.2011.14.4.023
  2. Cancer Pain Control for Advanced Cancer Patients by Using Autonomic Nerve Pharmacopuncture vol.17, pp.3, 2014, https://doi.org/10.3831/KPI.2014.17.028
  3. Trend Analysis of the Research on Bee Venom Acupuncture in South Korea, Based on Published Articles vol.36, pp.4, 2015, https://doi.org/10.13048/jkm.15036
  4. Risk Associated with Bee Venom Therapy: A Systematic Review and Meta-Analysis vol.10, pp.5, 2015, https://doi.org/10.1371/journal.pone.0126971