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The Effects of distilled Rehmannia glutinosa Herbal Acupuncture on the Heart Rate Variability(HRV)

생지황 약침이 정상인의 심박변이도(HRV)에 미치는 영향

  • Shin, Jin-Cheol (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Woosuk University) ;
  • Kim, Lak-Hyung (Dept. of Neuropsychiatry, College of Oriental Medicine, Woosuk University) ;
  • Song, Beom-Yong (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Woosuk University) ;
  • Yook, Tae-Han (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Woosuk University)
  • 신진철 (우석대학교 한의과대학 침구학교실) ;
  • 김락형 (우석대학교 한의과대학 신경정신과학교실) ;
  • 송범용 (우석대학교 한의과대학 침구학교실) ;
  • 육태한 (우석대학교 한의과대학 침구학교실)
  • Published : 2008.03.31

Abstract

Objectives : We investigated the effects of distilled Rehmannia glutinosa Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Rehmannia glutinosa Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 58 healthy volunteers consisted of 28 subjects in experiment(distilled Rehmannia glutinosa Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 28 subjects in experiment group were injected distilled Rehmannia glutinosa Herbal Acupuncture at $GB_{21}$(Kyonjong) and 30 subjects in control group were injected Normal Saline at $G_{21}$(Kyonjong). except of 2 subjects(in control group) who can't be measured and 6 subjects(2 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 26 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t-test(in group) and Student t-test(between two groups) were used to verify the result. Results : 1. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Mean HRV is significantly low only for first 5 minute, SDNN is significantly high after 5 minute, Complexity is significantly low only from 20 minute to 25 minute. HRV index is significantly high for first 5minute and from 10 minute to after 10 minute. 2. HRV index of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 25 minute to 30 minute, and pNN50 of Rehmannia glutinosa Herbal Acupuncture Group significantly decreased from 20 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Ln(TP) and Ln(VLF) are significantly high after injection. Normalized LF is significantly high from 5 minute to 20 minute and from 25 minute and 30 minute. Normalized HF is significantly low from 5minute to 20 minute and from 25 minute and 30 minute. 4. Ln(TP) and Ln(VLF) of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 20 minute to 25 minute compared with those of Normal Saline group. Conclusions : The results suggest that Rehmannia glutinosa Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system and parasympathetic nervous system compared to Normal Saline within normal range.

References

  1. 육창수. 한약학II. 서울:광명의학사. 1992:141
  2. 신민교. 원색임상본초학. 서울:남산당. 1986:218
  3. 이상인. 한약임상응용. 서울:성보사. 1986:199-201,254-355
  4. 신길구. 신씨본초학. 서울:수문사. 1981:92-3
  5. 대한약침학회. 약침요법 시술지침서. 서울:대한약침학회. 1999;13-4, 112-8,138-203
  6. 손인철. 약침요법. 서울:일중사. 1999;17-1
  7. 박정배, 김경식. 지황수침이 실험적 신성 고혈압 백서의 신장기능에 미치는 영향. 대한침구학회지. 1994;11(1):225-38
  8. 하춘자. 생지황의 Water Extract가 Alloxan 부하 생쥐 및 가토의 혈당치에 미치는 영향. 의학연구. 1979;79(1):135-42
  9. Akselrod S, Gordon D, Uble FA. Shannon DC, BargerAC, Cohen RJ. Power spectral analysis of heart rate fluctuation : a quantitative probe of beat-to-beat cardiovascular control. Science. 1981;213,220-2 https://doi.org/10.1126/science.6166045
  10. Akselrod S, Gordon D, Madwed JB, Snidman NC, Shannon DC, Cohen RJ. Hemodynamic regulation : Investigation by spectral analysis. Am J Physiol. 1985;249:867-75
  11. Cowan MJ. Measurement of heart rate variability. Western J Nursing Res. 1995;17:32-48 https://doi.org/10.1177/019394599501700104
  12. Cerutti S, Balzarotti R, Baselli G, Liberati D. Methods of Parametric Spectral Estimation applied to Biological Signal Processing. Biomed. Meas. Inform. Contr. 1986;1:114-24
  13. Haker E, Egekvist H, Bjerring P. Effect of sensory stimulation(acupuncture) on sympatheric and parasympathetic activities in healthy subjects. J Autonomic Nervous System. 2000;79:52-9 https://doi.org/10.1016/S0165-1838(99)00090-9
  14. 전국한의과대학 침구.경혈학교실 편저. 침구학 (상). 서울:집문당. 1999;45-71,279-80,634-5
  15. Mukai S, Hayano J. Heart rate and blood pressure variabilities during head up tilt. Jappl Physiol. 1995;78(1): 212-6
  16. 남동현, 박영배. 연령별 맥박변이도 표준화에 관한 연구. 대한한의진단학회지
  17. 손동혁. 마황복용이 정상인의 심박변이도에 미치는 영향. 우석대학교 한의학박사학위논문. 2006
  18. 이건영, 최준용, 정승연, 황준호, 이형구, 정승기, 정희재. 심박변이도 측정을 통한 수족다한증 환자의 자율신경계 기능평가. 대한한방내과학회지. 2005;11(1):46-51
  19. Ouyang H, Yin J, Wang Z, Pasricha PJ, Chen JDZ. Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J Physiol Gastrointest Liver Physiol. 2002;282(2):390-6
  20. Porta A, Baselli G, Rimoldi O, Malliani A, Pagani M. Assessing baroflex gain from spontaneous variability in conscious dogs : role of causality and respiration. Am J Physiol. 2000;279:2558-67
  21. 黃宮繡. 원광대학교 한의과대학 제21기 編譯. 本草求眞. 서울:木과土. 1999:676-7
  22. 구정회 외. 동약학개론. 서울:여강출판사. 1991:362-3
  23. 이창복. 대한식물도감. 서울:향문사. 1993:680
  24. 유경수. 지황의 수치에 관한 연구. 경희대논문집. 1965;4:233-52
  25. 홍선표 김용철, 김경호, 박정일, 박만기. 숙지황, 건지황 및 생지황 중 숙지황의 특이성분 검색. Journal of the Korean Society of Analytical Sciences. 1993;6(4):401-4
  26. 전병훈, 정우열. 실험적 혈전증에 미치는 한약재의 항혈전효과에 관한 연구. 대한동의병리학회지. 1996;10(1):72-8
  27. 황인진, 권강법, 조현익, 민영기, 허재혁, 김구환, 류도곤. 三種 地黃 추출물이 배양 심근세포에 미치는 영향. 동의생리병리학회지. 2002;16(6):1117-21
  28. Horn EH. Lee ST. Electronic evaluations of the fetal heart rate patterns preceding fetal death: further observation. Am J Obster Gynecol. 1995;87:824-6
  29. Saul JP, Arai Y, Berger RD, Lilly LS, Colucci WS, Cohen RJ. Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol. 1988;61:1292-9 https://doi.org/10.1016/0002-9149(88)91172-1
  30. 조정진. 직무 스트레스의 심혈관계 질환. 가정의학회지. 2002;23: 841-54
  31. 김범택. 비만환자에서 심박동수 변화. 가정의학회지. 2004;25: S542-6
  32. 김정아, 최윤선, 조경환, 홍명호. 주우울증 환자의 심박동 변이 분석. 가정의학회지. 2003;24:1117-22
  33. Yeragani VK, Srinivasan K, Vempati S, Pohl R, Balon R. Fractal dimension of heart rate time series: an effective measure of autonomic function. J Appl Physiol 1993;75:2429-38
  34. 김정민, 신민주, 이선희, 최환석, 옥선명, 김철민, 정기삼. 피로를 주소로 내원한 환자의 피로도에 따른 자율신경 변화. 가정의학회지. 2004;25:52-8
  35. 김민수, 곽민아, 장우석, 이기태, 정기삼, 정태영, 서정철, 서해경, 안희덕. 전침 자극이 정상 성인의 심박변동에 미치는 영향. 대한침구학회지. 2003;20(4):157-69
  36. 이상훈, 김은정, 박연철, 고영진, 남동우. 침자극이 뇌졸중 환자의 심박변이도에 미치는 영향. 대한침구학회지. 2006;23(1):135-43
  37. 장보형, 이정희, 문경숙, 김진원, 권오섭. 이침요법이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향. 대한침구학회지. 2005;22(6): 173-80
  38. 임대정, 황지혜, 황종순, 조현석, 김경호, 김갑성. HRV를 통한 말초성 안면신경마비와 자율신경실조의 상관성 연구. 대한침구학회지. 2005;22(6):51-60
  39. 설현, 육태한. 견정혈 황련해독탕약침이 심박변이율에 미치는 영향. 대한침구학회지. 2004;21(6):37-50
  40. 김정신, 황욱, 배기태, 남상수, 김용석. 소부(HT8) 자침이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향. 대한침구학회지. 2004;21(5):227-39
  41. Pomeranz B, Macaulay R, Caudill M, Kuts I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985;248:151-3
  42. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiolog. Heart rate variability : Standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043-65 https://doi.org/10.1161/01.CIR.93.5.1043
  43. Bigger JT, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE , Rottman JN. Frequency domain measures of heart period variability and mortality after myocardial infarction. Cir. 1992;85(1):164-71 https://doi.org/10.1161/01.CIR.85.1.164
  44. 이용제, 김문성, 김범택, 곽태환, 심재용, 이혜리. 대사증후군과 심박동수 변이와의 관계. 가정의학회지. 2003;23(12):1432-9
  45. 김동훈, 양동훈, 김은정, 남동우, 박연철, 박영재, 이상철, 박영배. 신문혈 자극과 한열성향의 교호작용이 심박변이도에 미치는 영향. 대한침구학회지. 2006;23(1):25-38

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