The study of relationship between the concentrations of Bisphenol A and DEHP in human plasma and precocious puberty

Bisphenol A와 DEHP의 혈중농도와 성조숙증 환아와의 상관성에 관한 연구

  • Han, Eunjung (Environmental Technology Research Center, Korea Institute of Science and Technology) ;
  • Yim, Okkyoung (Environmental Technology Research Center, Korea Institute of Science and Technology) ;
  • Chung, Jaeyeon (Environmental Technology Research Center, Korea Institute of Science and Technology) ;
  • Baek, Sunyoung (Environmental Technology Research Center, Korea Institute of Science and Technology) ;
  • Kim, Yunje (Environmental Technology Research Center, Korea Institute of Science and Technology)
  • 한은정 (한국과학기술연구원, 에너지환경연구본부, 환경기술연구단) ;
  • 임옥경 (한국과학기술연구원, 에너지환경연구본부, 환경기술연구단) ;
  • 정재연 (한국과학기술연구원, 에너지환경연구본부, 환경기술연구단) ;
  • 백선영 (한국과학기술연구원, 에너지환경연구본부, 환경기술연구단) ;
  • 김연제 (한국과학기술연구원, 에너지환경연구본부, 환경기술연구단)
  • Received : 2008.08.19
  • Accepted : 2008.10.06
  • Published : 2008.10.25

Abstract

Bisphenol A (BPA) and di-2-ethyhexyl phthalate (DEHP) is the considerably hazardous materials, endocrine disrupting chemicals (EDCs), which is accumulated to the human's fat and tissue. We studied the relationship between the concentrations of BPA and DEHP in the precocious puberty and the normal controls using GC/MSD. BPA concentrations of the precocious puberty are lower than that of normal controls. But DEHP concentrations of the precocious puberty are higher than that of normal controls. From these results, BPA is not related to the precocious puberty. Otherwise, DEHP is somewhat related to the precocious puberty and the concentrations of the precocious puberty are approximately 45% higher than that of normal controls.

Keywords

Bisphenol A;DEHP;precocious puberty;GC/MSD

References

  1. K. Shiota and S Mima, Arch Toxicol, 56, 263-266(1985) https://doi.org/10.1007/BF00295165
  2. D. A. Key, D. G. Wallace, T. B. Kepler and R. B. Conolly, Toxicol Sci, 49, 172-185(1995) https://doi.org/10.1093/toxsci/49.2.172
  3. E. C. Dodds and W. Lawson, Nature, 137, 996-996(1936)
  4. R. T. Zoeller, R. Bansal and C. Parris, Endocrinology, 146, 607-612(2005) https://doi.org/10.1210/en.2004-1018
  5. M. Sugiura-Ogasawara, Y. Ozaki, S. Sonta, T. Makino and K. Suzumori, Hum. Reprod, 20, 2325-2329(2005) https://doi.org/10.1093/humrep/deh888
  6. N. R. Lazer, Adv Material Processes, 147, 43-45(1995)
  7. D. K. Agarwal, S. Eustis, J. C. Lamb, J. R. Real and W. I. M. Kluwe, Environ Health Perspect, 65, 343-350(1986) https://doi.org/10.2307/3430202
  8. I. Colon, D. Caro and C. J. Bourdony, Environ Health Perspect., 108, 895-900(2000) https://doi.org/10.1289/ehp.00108s5895
  9. G. Berkowitz, Hum. Reprod, 21, 565-566(2000)
  10. Y. B. Wetherill, C. E. Petre, K. R. Monk, A. Puga and K. E. Knudsen, Mol. Cancer Ther., 7, 515-524(2002)
  11. K. N. Woodward, Him Exp Toxicol, 9, 397-401(1990) https://doi.org/10.1177/096032719000900607
  12. S. Oishi, S. P. Serivastava, G. B. Singh and P. K. Seth, Toxicol Lett, 36, 297-308(1987) https://doi.org/10.1016/0378-4274(87)90199-8