A T-cell type multicentric Lymphoma affecting central nervous system in a Cocker Spaniel dog

  • Kim, Ju-Won (College of Veterinary Medicine, Konkuk University) ;
  • Jung, Dong-In (College of Veterinary Medicine, Konkuk University) ;
  • Kang, Byeong-Teck (College of Veterinary Medicine, Konkuk University) ;
  • Yoo, Jong-Hyun (BK21 Program of Integrative Network system for Veterinarians in Basic Science, Industrial Animals and Preventive Medicines, Konkuk University) ;
  • Park, Chul (School of Veterinary Medicine, University of California) ;
  • Kim, Dae-Young (College of Veterinary Medicine, University of Missouri-Columbia) ;
  • Park, Hee-Myung (College of Veterinary Medicine, Konkuk University)
  • Accepted : 2008.09.17
  • Published : 2008.12.01

Abstract

A 4-year-old female Cocker spaniel was presented with respiratory distress and abdominal distension. Pleural effusion, ascites, hepatosplenomegaly, and superficial lymphadenopathy were observed and multicentric lymphoma was diagnosed by cytological examination. Immunophenotyping of lymph node and bone marrow using polymerase chain reaction for antigen receptor rearrangement identified a stage V lymphoma originating from T-cell. Despite of systemic chemotherapy using L-asparagenase, vincristine, cyclophoaphamide and prednisolone, neurologic deficits came out and progressed. Cerebrospinal fluid analysis revealed neoplastic lymphocytic pleocytosis indicating central nervous system involvement of lymphoma. The postmortem diagnosis was confirmed based on the histology and imunohistochemistry.

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