Granulosa cell tumor in a sow

돼지의 과립막세포 종양

  • Accepted : 2008.06.16
  • Published : 2008.12.01


A two-year-old mixed breed sow was requested to the Veterinary Pathology Laboratory of Cheju National University with a clinical signs of severe abdominal pain and sudden death. Grossly, there was severe hemorrhage in abdominal cavity. Most of internal parenchymas and subcutaneous muscle showed severe pale discoloration. Both ovaries were enlarged with oval to round protruding multilobular masses and dark red in color. And they were firm and contained multiple small cysts in their cut surface. Histopathologically, numerous neoplastic granulosa cells had spherical-to-oval, hyperchromatic nuclei and scant eosinophilic cytoplasms were distributed with follicular pattern in ovarian masses. And the typical Call-Exner bodies, distinctive microcavityies, were observed in the center of small neoplastic follicles. Based on the gross and histopathologic findings, this case was diagnosed as granulosa cell tumor. In our best knowledge, this is believed to be the first report of granulosa cell tumor in a sow in Korea.


  1. 김병선, 이치중, 성영미, 홍서유. 난소종양의 조직병리학적 및 임상 고찰. 대한산부인과학회지 1991, 34, 81-90
  2. 정해련, 고승권, 한지영, 송은섭, 박지현, 이건영, 황성욱, 임문환, 이병익, 이우영. 과립막세포종 5예. 대한산부인과학회지 2004, 47, 212-219
  3. Akihara Y, Shimoyama Y, Kawasako K, Komioe M, Hirayama K, Kagawa Y, Omachi T, Matsuda K, Okamoto M, Kadosawa T, Taniyama H. Immunohistochemical evaluation of canine ovarian tumors. J Vet Med Sci 2007, 69, 703-708
  4. Akkermans JP, van Beusekom WJ. Tumors and tumor-like lesions in the genitalia of sows. Vet Q 1984, 6, 90-96
  5. Ellenberger C, Bartmann CP, Hoppep HO, Kratzsch J , AupperJe H, Klug E, Schoon D, Schoon HA. Histomorphological and immunohistochemical characterization of equine granulosa cell tumours. J Comp Pathol 2007, 136, 167-176
  6. Fullerer PJ, Chu S. Signalling pathways in the molecular pathogenesis of ovarian granulosa cell tumours. Trends Endocrinol Metab 2004,15, 122-128
  7. Kennedy PC, Cullen JM, Edwards JF, Goldschmidt MH, Larsen S, Munson L, Nielsen S. Histological Classification of Tumors of the Genital System of Domestic Animals. 2nd series. Vol. IV. pp. 24-28, Armed Forces Instirute of Pathology, Washington DC, 1998
  8. MacLachlan NJ, Kennedy PC. Twnors of the genital systems. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 550-553, Iowa State University Press, Ames, 2002
  9. Masseau I, Feeteau G, Desroehers A, Francoz D, Lanthier I, Vaillancoun D. Hemoperitoneum caused by the rupture of a granulosa cell tumor in a Holstein heifer. Can Vet J 2004, 45, 504-506
  10. Maurice KT. Diagnosis and surgical removal of a granulosa-theca cell tumor in a mare. Can Vet J 2005, 46, 644-646
  11. Patrick DJ, Kiupel M, Gerber V, Carr EA. Malignant granulosa-theca cell tumor in a two-year-old miniature horse. J Vet Diagn Invest 2003, 15, 60-63
  12. Plourde V, Martineau R, Harvey D. Surgical removal of a granulosa cell turnor from a heifer. Can Vet J 1984, 25, 12-13
  13. Sung JH, Yoo JH, Kang BT, Park C, Jung DI, Park JI, Park HM. Granulosa cell tumor of ovary in a Yorkshire terrier dog. J Vet Clin 2007, 24, 38-41