A comparison of single dose efficacy of Mycoplasma hyopneumoniae bacterin in swine farms with different serological patterns of PRRSV and PCV2

  • Kim, Hye Kwon (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Moon, Hyoung Joon (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Eun Mi (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Yang, Jeong Sun (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Pakr, Seong Jun (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Luo, Yuzi (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Lee, Chul Seung (Research Unit, Green Cross Veterinary Products) ;
  • Song, Dae Sub (Research Unit, Green Cross Veterinary Products) ;
  • Kang, Bo Kyu (Research Unit, Green Cross Veterinary Products) ;
  • Lee, Jaebum (Hankuk Academy of Foreign Studies) ;
  • Park, Bong Kyun (College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
  • Accepted : 2008.08.01
  • Published : 2008.12.01

Abstract

This study was to evaluate the efficacy of single dose Mycoplasma hyopneumoniae (M. hyo)-vaccination in the swine farms which had different serological patterns of porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2). A minimum of 240 pigs from each farm was applied, allocating M. hyo vaccinated and control groups. The PRRSV and PCV2 infections were analyzed by serological method (commercial ELISA kit). After administrating pigs a single dose of M. hyo vaccine or control saline at 3 weeks of age, serum antibodies to M. hyo, PRRSV and PCV2 were monitored at 4, 10, 16 and 22 weeks of age. Mortality, weight changes, feed conversion ratio (FCR) and lung score were also evaluated. A single-dose vaccination of M. hyo bacterin was efficacious to reduce mycoplasmal lung lesions and induce good humoral immune response. However, FCR was improved only in one of the three farms where showed seronegative status to both PRRSV and PCV2 in the period from 4 to 16 weeks of age. These results might imply that M. hyo vaccine alone could not overcome the PRRSV and PCV2 infection-associated wasting in the field condition. Therefore, the control of PRRSV and PCV2 should be considered to obtain the better effects of M. hyo vaccination.

Acknowledgement

Supported by : Research Institute for Veterinary Science

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