Quantitative analysis of phosphorus by HERETIC-NMR method

HERETIC-NMR법을 이용한 인의 정량분석

  • Lim, Heon-Sung (Center for Chemical Analysis, Korea Research Institute of Chemical Technology) ;
  • Park, Chan-Jo (Center for Chemical Analysis, Korea Research Institute of Chemical Technology) ;
  • Lee, Sueg-Geun (Center for Chemical Analysis, Korea Research Institute of Chemical Technology)
  • 임헌성 (한국화학연구원 화학분석센터) ;
  • 박찬조 (한국화학연구원 화학분석센터) ;
  • 이석근 (한국화학연구원 화학분석센터)
  • Received : 2008.07.28
  • Accepted : 2008.10.06
  • Published : 2008.10.25


We have developed an alternative to the internal chemical reference based on a calibrated reference signal which is not a real NMR line but an electronically produced signal (HERETIC) and determined the phosphorus concentration using this method. The area ratio of HERETIC and sample peaks obtained from the standard samples was used to measure the concentrations of different samples directly. The analysis of phosphorus by this method showed the excellent linear regression coefficient ($R^2=0.9999$) for the concentration range from 20 ppm to 500 ppm with HERETIC peak as reference.


phosphorus analysis;NMR;HERETIC


  1. G. S. Remaud, V. Silvestre and S. Akoka, Accred. Qual. Assur., 10, 415(2005) https://doi.org/10.1007/s00769-005-0044-1
  2. S. G. Lee, Bull. Korean Chem. Soc. 28(10), 1635(2007) https://doi.org/10.5012/bkcs.2007.28.10.1635
  3. J. G. Verkade and L. D. Quin, 'Methods in Stereochemical Analysis', Vol. 8. 'Phosphorus-31 NMR Spectroscopy in Stereochemical Analysis', VCH Publishers, Inc., 1987 and references cited therein
  4. C. N. Ho and S. L. Lam, J. Magn. Reson., 171, 193(2004) https://doi.org/10.1016/j.jmr.2004.08.024
  5. J. Mendham, R. C. Denney, J. D. Barnes and M. J. K. Thomas, In Vogel's Quantitative Chemical Analysis, 6th ed.; Prentice Hall: England, 2000; Chap. 14 and references cited therein
  6. 이석근, '핵 자기공명 분광학', 63-68, 자유아카데미, 2002
  7. S. Akoka, L. Barantin and M. Trierweiler, Anal. Chem., 71, 2554(1999) https://doi.org/10.1021/ac981422i
  8. A. V. Lebedev and A. I. Rezvukhin, Nucleic Acids Res., 12(14), 5547(1984) https://doi.org/10.1093/nar/12.14.5547
  9. S. G. Lee, J. Kor. Magn. Reson., 11(2), 115(2007)
  10. J. N. Shooley, Progr. NMR Spectrosc. 11, 79(1977) https://doi.org/10.1016/0079-6565(77)80003-4
  11. T. J. Kim, Anal. Sci. Tech., 5(1), 13A(1992)
  12. V. Silvestri, S. Goupry, M. Trierweiler, R. Robins and S. Akoka, Anal. Chem., 73, 1862(2001) https://doi.org/10.1021/ac0013204