Growth Hormone Signaling in the Regulation of Acid Labile Subunit

Kim, Jin Wook;Boisclair, Yves R.

  • Received : 2007.09.05
  • Accepted : 2007.11.12
  • Published : 2008.05.01


The past decades have seen enormous advances in our understanding of how GH acts. GH is a pituitary-derived polypeptide hormone that has diverse physiological effects including the regulation of bone growth, carbohydrate and lipid metabolism. The effects of GH are mediated directly and indirectly through IGF-I. In addition, GH stimulates the hepatic production of ALS. In postnatal life, IGF-I and -II circulate as 150 kDa ternary complexes consisting of one molecule each of IGFBP-3 or IGFBP-5, IGF-I or IGF-II and ALS. It is now known that ALS increases significantly the half-lives of the IGFs, IGFBP-3 and -5, and therefore is responsible for maintaining a circulating reservoir for each of these proteins.


Growth Hormone;Signaling;Acid Labile Subunit


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