Structure elucidation and determination of illegal compounds (Anti-impotance drug analogues) in foods

식품 중 부정유해물질 (발기부전치료제 유사물질) 구조규명 및 분석

  • Choi, Dongmi (New Hazard Chemicals Division, Korea Food & Drug Administration)
  • 최동미 (식품의약품안전청, 신종유해물질과)
  • Received : 2007.08.16
  • Accepted : 2008.04.02
  • Published : 2008.04.25

Abstract

It is noted that illegal hazardous foods containing unauthorized drugs or synthetic drung analogues are increasing. Especially, reported are unknown compounds that have the modified chemical structures of the anti-impotence drugs such as sildenafil, vardenafil, and tatalafil. In addition, it is very reserved, since illegal synthetic compounds having similar chemical structures modified from anti-impotence drug to avoid the government inspection are not proved their safety at all. This review in ulation to food safety, lists the illegal compounds added to foods and describes about the analytical methods to chanacterize 16 anti-impotence drug analogues such as homosildenafil, hongdenafil, pseudovardenafil, aminotadalafil, hydroxyhomosildenafil, hydroxyhongdenafil, dimethylsildenafil, xanthoanthrafil, hydroxyvardenafil, norneosildenafil, demethylhongdenafil, piperidinohongdenafil, carbodenafil, thiosildenafil, dimethylthiosildenafil, and acetylvardenafil.

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