Rheological Properties of Calcium Phosphate Cement Mixed with 2 Kinds of Setting Solution

2종의 경화액과 혼합된 calcium phosphate cement의 유변학적 성질에 관한 연구

  • Chang, Seok-Woo (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kwon, Ho-Beom (Department of Prosthodontics, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yoo, Hyun-Mi (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Dong-Sung (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Oh, Tae-Seok (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Bae, Kwang-Shik (Department of Conservative Dentistry, School of Dentistry, Seoul National University)
  • 장석우 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 권호범 (성균관대학교 의과대학 삼성서울병원 치과진료부 보철과) ;
  • 유현미 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 박동성 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 오태석 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 배광식 (서울대학교 치의학전문대학원 보존학 교실)
  • Received : 2008.05.15
  • Accepted : 2008.09.25
  • Published : 2008.09.30

Abstract

Calcium phosphate cement (CPC) has been used as bone substitute successfully due to good biocompatibility and osteoconductivity. One of the important mechanical characteristics of CPC is flowablility, which can be evaluated by measuring rheological parameters. However, there have been few studies that measured rheological properties of CPC. The purpose of this study was to evaluate the rheological properties of CPC paste mixed with 2 kinds of setting solutions, 2% hydroxyprophyl methylcellulose (HPMC) and 35% polyacrylic acid (PAA). The CPC used was dicalcium phosphate dihydrate (DCPD). Rheological properties of CPC paste were measured using rheometer. The statistical analysis was carried out with Mann-whitney test with Bonferronis collection. CPC with both setting solutions showed shear thinning behavior. CPC with 2% HPMC showed signigicantly higher complex viscosity than CPC with 35% PAA(p<0.05).

Keywords

calcium phosphate cement;hydroxyprophyl methylcellulose;polyacrylic acid;theological characteristics

References

  1. Yang SE, Baek SH, Lee W, Kum KY, Bae KS. In vitro evaluation of the sealing ability of newly developed calcium phosphate-based root canal sealer. J Endod 2007;33:978-81 https://doi.org/10.1016/j.joen.2006.07.023
  2. Ambard AJ, Mueninghoff L. Calcium phosphate cement: review of mechanical and biological properties. J Prosthodont 2006;15:321-8 https://doi.org/10.1111/j.1532-849X.2006.00129.x
  3. Wang X, Ye J, Wang H. Effects of additives on the rheological properties and injectability of a calcium phosphate bone substitute material. J Biomed Mater Res B Appl Biomater 2006;78:259-64
  4. Liu C, Shao H, Chen F, Zheng H. Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry. Biomaterials 2006;27: 5003-13 https://doi.org/10.1016/j.biomaterials.2006.05.043
  5. Wang X, Chen L, Xiang H, Ye J. Influence of anti-washout agents on the rheological properties and injectability of a calcium phosphate cement. J Biomed Mater Res B Appl Biomater 2007;81:410-8
  6. Leroux L, Hatim Z, Freche M, Lacout JL. Effects of various adjuvants (lactic acid, glycerol, and chitosan) on the injectability of a calcium phosphate cement. Bone 1999;25:31S-4S https://doi.org/10.1016/S8756-3282(99)00130-1
  7. Burguera EF, Xu HH, Weir MD. Injectable and rapid-setting calcium phosphate bone cement with dicalcium phosphate dihydrate. J Biomed Mater Res B Appl Biomater 2006;77:126-34
  8. Alves HL, Dos Santos LA, Bergmann CP. Injectability evaluation of tricalcium phosphate bone cement. J Mater Sci Mater Med 2008;19:2241-6 https://doi.org/10.1007/s10856-007-3329-6
  9. Burguera EF, Guitian F, Chow LC. A water setting tetracalcium phosphate-dicalcium phosphate dihydrate cement. J Biomed Mater Res A 2004;71:275-82
  10. Schirrmeister JF, Kielbassa AM. Coronal leakage of calcium phosphate-based root canal sealers compared with usual sealers. Schweiz Monatsschr Zahnmed 2006;116:224-8
  11. Ginebra MP, Fernandez E, De Maeyer EA, Verbeeck RM, Boltong MG, Ginebra J, et al. Setting reaction and hardening of an apatitic calcium phosphate cement. J Dent Res 1997;76:905-12 https://doi.org/10.1177/00220345970760041201
  12. Baroud G, Matsushita C, Samara M, Beckman L, Steffen T. Influence of oscillatory mixing on the injectability of three acrylic and two calcium- phosphate bone cements for vertebroplasty. J Biomed Mater Res B Appl Biomater 2004;68:105-11
  13. Shirakata Y, Yoshimoto T, Goto H, Yonamine Y, Kadomatsu H, Miyamoto M, et al. Favorable periodontal healing of 1-wall infrabony defects after application of calcium phosphate cement wall alone or in combination with enamel matrix derivative: a pilot study with canine mandibles. J Periodontol 2007;78:889-98 https://doi.org/10.1902/jop.2007.060353
  14. Bohner M, Baroud G. Injectability of calcium phosphate pastes. Biomaterials 2005;26:1553-63 https://doi.org/10.1016/j.biomaterials.2004.05.010
  15. Jack V, Buchanan FJ, Dunne NJ. Particle attrition of alpha-tricalcium phosphate: effect on mechanical, handling, and injectability properties of calcium phosphate cements. Proc Inst Mech Eng [H] 2008;222:19-28
  16. Xu HH, Takagi S, Sun L, Hussain L, Chow LC, Guthrie WF, et al. Development of a nonrigid, durable calcium phosphate cement for use in periodontal bone repair. J Am Dent Assoc 2006;137: 1131-8 https://doi.org/10.14219/jada.archive.2006.0353
  17. Sugawara A, Fujikawa K, Kusama K, Nishiyama M, Murai S, Takagi S, et al. Histopathologic reaction of a calcium phosphate cement for alveolar ridge augmentation. J Biomed Mater Res 2002;61:47-52 https://doi.org/10.1002/jbm.10010
  18. Baroud G, Bohner M, Heini P, Steffen T. Injection biomechanics of bone cements used in vertebroplasty. Biomed Mater Eng 2004;14:487-504
  19. Cherng A, Takagi S, Chow LC. Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement. J Biomed Mater Res 1997;35: 273-7 https://doi.org/10.1002/(SICI)1097-4636(19970605)35:3<273::AID-JBM1>3.0.CO;2-E
  20. Comuzzi L, Ooms E, Jansen JA. Injectable calcium phosphate cement as a filler for bone defects around oral implants: an experimental study in goats. Clin Oral Implants Res 2002;13:304-11 https://doi.org/10.1034/j.1600-0501.2002.130311.x
  21. Wang X, Ye J, Wang Y, Chen L. Self-setting properties of a beta-dicalcium silicate reinforced calcium phosphate cement. J Biomed Mater Res B Appl Biomater 2007;82:93-9