Theoretical Consideration of the Modified Haldane Model of the Substrate Inhibition in the Microbial Growth Processes

미생물 성장 공정에서의 기질 저해에 관한 modified Haldane 모델의 이론적 고찰

  • Hwang, Young-Bo (School of Material Science & Nano Chemical Engineering, Kunsan National University)
  • 황영보 (군산대학교 공과대학 신소재.나노화학공학부)
  • Received : 2008.01.09
  • Accepted : 2008.03.26
  • Published : 2008.06.10

Abstract

This paper deals with the theoretical derivation of the modified Haldane model of the substrate inhibition in the microbial growth processes. Based on the biological concepts of substrate-receptor complex working mechanisms, a new microbial kinetics of N-fold multiplex substrate inhibition and its generalization has been considered theoretically, which is natural expansion of the simple substrate inhibition mechanism in the enzyme reaction. As a result, the modified Haldane model of the substrate inhibition turns out to be a well-designed four-parameter kinetic model with a biological constant of the total substrate inhibition concentration.

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