A case of transitional carcinoma in the nasal cavity of a dog

개의 비강 내 이행암종 증례

  • Kang, Hwa-Jung (College of Veterinary Medicine, Cheju National University) ;
  • Kang, Sang-Chul (Preclinical Research Center, Chemon Inc) ;
  • Jung, Ji-Youl (College of Veterinary Medicine, Cheju National University) ;
  • Jo, Suk-Hee (College of Veterinary Medicine, Cheju National University) ;
  • Roh, In-Soon (National Veterinary Research and Quarantine Service) ;
  • Lee, Joo-Myung (College of Veterinary Medicine, Cheju National University) ;
  • Cheong, Jongtae (College of Veterinary Medicine, Cheju National University) ;
  • Kim, Jung-Hun (College of Veterinary Medicine, Cheju National University) ;
  • An, Min-Chan (Halla Pet Hospital) ;
  • Bae, Jong-Hee (College of Veterinary Medicine, Cheju National University) ;
  • Kim, Jae-Hoon (College of Veterinary Medicine, Cheju National University)
  • Accepted : 2008.09.12
  • Published : 2008.12.01


A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass was detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and $2.5{\times}4cm$ cm in size. Histopathologically, the mass was composed of mediumsized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratin (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.


  1. 권정국, 송경진, 이기창, 이희천, 최민철. 개의 비강편평상피세포종의 컴퓨터단층촬영상의 특징. 한국임상수의학회지 2003, 20, 399-402
  2. 정주현, 장진화, 오선경, 김경민, 이성옥, 이정민, 김학상, 윤정희, 최민철. 개에서 비강 샘암종의 영상 진단 증례. 한국임상수의학회지 2006, 23, 355-360
  3. 최을수, 김민규, 윤화영, 이창우. 개 원발성 비강내 전염성 성병성 종양 예. 한국임상수의학회지 2002, 19, 360-362
  4. 홍성혁, 김명철. CT 진단 후 비절개술 및 방사선요법으로 치료한 개의 비강 선암의 발생례. 한국임상수의학회지 2002, 19, 256-259
  5. Caswell JL, Williams KJ. Respiratory system. In: Maxie MG, Jubb KVF, Palmer N (eds.). Pathology of Domestic Animals. 5th ed. pp. 535-537, Elsevier, Edinburgh, 2007
  6. Confer AW. DePaoli A. Primary neoplasms of the nasal cavity, paranasaI sinuses and nasopharynx in the dog. A report of 16 cases from the files of the AFIP. Vet Pathol 1978, 15, 18-30 https://doi.org/10.1177/030098587801500103
  7. Correa SS. Mauldin GN, Mauldin GE, Patnaik AK. Efficacy of cobalt-60 radiation therapy for the treatment of nasal cavity nonkeratinizing squamous cell carcinoma in the dog. J Am Anim Hosp Assoc 2003, 39, 86-89 https://doi.org/10.5326/0390086
  8. Forrest LJ. The cranial and nasal cavity: Canine and feline. In: Thrall DE (ed.). Textbook of Veterinary Diagnostic Radiology. 5th ed. pp. 119-141 , Elscvier, St. Louis, 2007
  9. Franchi A, Moroni M, Massi D, Paglierani M, Santucci M. Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns. Am J Surg Pathol 2002, 26, 1597-1604 https://doi.org/10.1097/00000478-200212000-00007
  10. Harkema JR, Carey SA, Wagner JG. The nose revisited: A brief review of the comparative structure, function, and toxicologic pathology of the nasal epithelium. ToxicoI Pathol 2006, 34, 252-269 https://doi.org/10.1080/01926230600713475
  11. Madewell BR, Priester WA, Gillette EL, Snyder SP. Neoplasms of the nasal passages and paranasaI sinuses in domesticated animals as reported by 13 veterinary colleges. Am J Vet Res 1976, 37, 851-856
  12. Reif JS, Bruns C, Lower KS. Cancer of the nasal cavity and paranasaI sinuses and exposure to environmental tobacco smoke in pet dogs. Am J Epidemiol 1998, 147, 488-492 https://doi.org/10.1093/oxfordjournals.aje.a009475
  13. Wilson DW, Dungworth DL. Tumors of the resporatory tract. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 365-373, Iowa State University Press, Ames, 2002