Antimicrobial resistance and transfer of R plasmid of pathogenic Eseherichia coli isolated from poultry in Korea

가금 유래 병원성 대장균의 항균제 내성 및 R plasmid 전달 양상

  • Sung, Myung-Suk (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Jin-Hyun (College of Veterinary Medicine, Kyungpook National University) ;
  • Cho, Jae-Keun (Health & Environmental Research Institute) ;
  • Seol, Sung-Yong (Kyungpook National University School of Medicine) ;
  • Kim, Ki-Seuk (College of Veterinary Medicine, Kyungpook National University)
  • 성명숙 (경북대학교 수의과대학) ;
  • 김진현 (경북대학교 수의과대학) ;
  • 조재근 (대구시 보건환경연구원) ;
  • 설성용 (경북대학교 의학전문대학원) ;
  • 김기석 (경북대학교 수의과대학)
  • Accepted : 2008.08.01
  • Published : 2008.12.01

Abstract

Antimicrobial drugs are widely used in poultry industry as growth promoters or to control infectious diseases. However, this practice is reported to have caused high resistance to antimicrobial drugs in normal chicken flora and pathogens. Antimicrobial resistance to Escherichia coli (E. coli) from chicken has been mainly reported in normal flora, but rare in pathogenic organism in Korea, recently. Therefore, this study was conducted to investigate prevalence of antimicrobials resistance, transfer of R plasmid, and association between antimicrobial drug resistance and O serotype of 203 pathogenic E. coli from poultry in Korea during the period from April 2003 to December 2005. These isolates showed a high resistance to tetracycline (Tc, 93.6%), nalidixic acid (Na, 92.6%), streptomycin (Sm, 81.8%), ampicillin (Ap, 77.3%), ciprofloxacin (Ci, 70.9%), sulfisoxazole (Su, 66.5%), and trimethoprim (Tp, 58.1%). Two hundred-one (99.0%) of the isolates were resistant to one or more drugs. They showed 57 different resistant patterns, and the most prevalent resistant pattern among them was Tc, Sin, Su, Ap, Tp, Ci, Na. Sixty-eight (33.8%) of the isolates transferred all or a part of their antimicrobial resistant pattern to the recipient strain by R plasmid. The most common antimicrobial resistant pattern was Tc, Sm, Su, Ap, Tp, Ci, Na in serotype O78, O88 and O15, respectively. These results exhibit high individual and multiple resistance to antimicrobials of pathogenic E. coli from poultry in Korea. They also suggest the needs for surveillance to monitor antimicrobial resistance in pathogenic bacteria that can be potentially transmitted to humans from food animals and to regulate the abuse of antimicrobials on food-producing animals in Korea.

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