Association Analysis between Insulin-like Growth Factor Binding Protein 3 (IGFBP3) Polymorphisms and Carcass Traits in Cattle

  • Cheong, Hyun Sub (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Yoon, Du-Hak (National Institute of Animal Science, RDA.) ;
  • Kim, Lyoung Hyo (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Park, Byung Lae (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Lee, Hye Won (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Namgoong, Sohg (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Kim, Eun Mi (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Chung, Eui Ryong (Department of Biotechnology, Sangji University) ;
  • Cheong, Il-Cheong (National Institute of Animal Science, RDA) ;
  • Shin, Hyoung Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
  • Received : 2006.08.09
  • Accepted : 2007.04.07
  • Published : 2008.03.01


The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.


IGFBP3;Cold Carcass Weight;Marbling Score;Polymorphism


Supported by : Agriculture and Forestry, Ministry of Agriculture and Forestry


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