Detection of Helicobacter Pylori in Saliva of Korean Infant

한국인 소아의 타액에서 Helicobacter pylori의 검출

  • Ryu, Ji-Won (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Lee, Jang-Keun (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Lee, Yong-Su (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Yoon, Chang-Lyuk (Department of Oral Medicine, College of Dentistry, Chosun University) ;
  • Ahn, Jong-Mo (Department of Oral Medicine, College of Dentistry, Chosun University)
  • 유지원 (조선대학교 치과대학 구강내과학교실) ;
  • 이장근 (조선대학교 치과대학 구강내과학교실) ;
  • 이영수 (조선대학교 치과대학 구강내과학교실) ;
  • 윤창륙 (조선대학교 치과대학 구강내과학교실) ;
  • 안종모 (조선대학교 치과대학 구강내과학교실)
  • Published : 2008.03.30


Helicobacter pylori(H. pylori) has been associated with the cause of peptic ulcer and gastric cancer. H. pylori infection occur mostly during childhood and increase by aging. In route of transmission, Oral cavity does important role. So we employed this study to elucidate route of transmission by detection of H. pylori in infant saliva. We investigated 20 infants aged below 10 years and 20 teens aged below 20 years as study group and 71 adults aged 20 and over years as control group. H. pylori DNA was isolated from 5(25%) infants aged below 10 years, 6(30%) teens and 17(23.9%) adults by nested polymerase chain reaction(n-PCR). There was no statistically significant difference(P>0.05). The obtained results suggest that H. pylori infection is relatively common in saliva of Korean infant and oral cavity may be reservoir of H. pylori.


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