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막걸리 분획물에 의한 암세포 성장 억제 및 Quinone Reductase 활성 증가 효과

Effect of Growth Inhibition and Quinone Reductase Activity Stimulation of Makgeoly Fractions in Various Cancer Cells

  • 신미옥 (신라대학교 식품영양학과, 마린-바이오 산업화지원센터) ;
  • 강대연 (신라대학교 식품영양학과, 마린-바이오 산업화지원센터) ;
  • 김미향 (신라대학교 식품영양학과, 마린-바이오 산업화지원센터) ;
  • 배송자 (신라대학교 식품영양학과, 마린-바이오 산업화지원센터)
  • Shin, Mi-Ok (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University) ;
  • Kang, Dae-Yeon (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University) ;
  • Kim, Mi-Hyang (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University) ;
  • Bae, Song-Ja (Dept. of Food and Nutrition, Marine Biotechnology Center for Biofunctional Material Industries, Silla University)
  • 발행 : 2008.03.31

초록

막걸리의 암 예방효과를 알아보기 위하여 막걸리 농축물을 핵산, 메탄올, 부탄올 및 물로 순차적으로 분획하여 각 분획별로 암세포에 대한 성장 억제효과와 암 예방 지표인 QR활성 증가 효과를 측정하였다. 그 결과 메탄올 분획물의 경우 낮은 농도의 시료첨가에도 불구하고 괄목할 만한 높은 암세포 성장 억제효과를 나타내었으며 4종의 모든 암세포주 HepG2, B16-F10, HT29 및 MCF-7에서 농도 의존적인 암세포 성장 억제효과를 나타내었다. 또한 HepG2에서 측정한 QR활성 증가 효과에 있어서도 메탄올 분획물이 가장 높은 QR활성 증가 효과를 보여 암에 대한 예방효과가 기대된다. 따라서 앞으로 막걸리를 이용하여 항암관련 기능성식품을 개발할 수 있는 가능성이 보이며, 이를 위하여 특히 메탄올 분획물에 대한 집중적인 연구가 요구된다.

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