Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Paecilomyces tenuipes Water Extract on the Alcohol Metabolism of Rats

눈꽃동충하초 물추출물이 흰쥐의 알코올대사에 미치는 영향

  • Kim, Ji-Myung (Dept. of Food and Nutritional Sciences, Hanbuk University) ;
  • Park, Jae-Hwan (Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Mi-Kyung (Dept. of Food and Nutritional Science, Ewha Womans University) ;
  • Chun, Hyang-Sook (Food Convergence Technology Division, Korea Food Research Institute)
  • Published : 2008.03.31

Abstract

The effect of Paecilomyces tenuipes water extract (PTWE) on the alcohol metabolism was examined on rats. PTWE of 0, 30, 100 mg/kg body weight was administrated orally to the rats 30 min before oral treatment of 3 g/kg body weight of alcohol. Blood alcohol and acetaldehyde concentrations were measured 0.5, 1, 3, 6, 9 hr after alcohol treatment. Hepatic alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ADH), microsomal ethanol oxidizing system (MEOS) activities were measured 9 hr after alcohol treatment. There were no differences in blood alcohol concentrations and area under the curve (AUC) of alcohol. PTWE decreased acetaldehyde concentration and there were significant differences after 6 hr in 30 mg/kg PTWE and after 3 and 9 hr in 100 mg/kg PTWE, respectively. In particular, 100 mg/kg PTWE decreased AUC of acetaldehyde by 44%. However, there were no changes in the hepatic ADH, ALDH, and MEOS activities.

Keywords

File

Download PDF

References

  1. Cho SY. 1999. Cultivation and distribution of silkworm-dongchunghacho (Paecilomyces japonica). Paper presented at 1st International Symposium on Cordyceps. The Korean Society Sericultural Science and the Korean Society of Life Science, Seoul, Korea. p 73-82
  2. Shim JS, Min EG, Han YH. 2000. Cytotoxicity against human cancer cell lines by Paecilomyces tenuipes DUGM 32001. Kor J Microbiol 36: 312-315
  3. Kwon SH, Woo HJ, Han DS, Kim MK. 2001. Effect of dried powders and water extracts of Paecilomyces tenuipes and Cordyceps militaris on lipid metabolism, antioxidative capacity and immune status in rats. Kor J Nutr 34: 271-284
  4. Lieber CS. 1994. Alcohol and the liver: 1994 Update. Gastroenterol 106: 1085-1105 https://doi.org/10.1016/0016-5085(94)90772-2
  5. Ramchandani VA, Bosron WF, Li TK. 2001. Research advances in ethanol metabolism. Pathol Biol 49: 676-682 https://doi.org/10.1016/S0369-8114(01)00232-2
  6. Park SC. 1993. Ethanol oxidation is accelerated by augmentation of malate-aspartate shuttle with aspartate. Kor J Biochem 25: 137-143
  7. Kim CI. 1999. Cause and effect of hangover. Food Ind Nutr 4: 26-30
  8. Jornvall H, Hoog JO, Bahr-Lindstrom H, Johanson J, Kaiser R, Person R. 1988. Alcohol dehydrogenase and aldehyde dehydrogenase. Biochem Soc Trans 16: 223-227 https://doi.org/10.1042/bst0160223
  9. Shim JY, Lee YS, Lim SS, Shin KH, Hyun JE, Kim SY, Lee EB. 2000. Pharmacological activities of Paecilomyces japonica, a new type Cordyceps sp. Kor J Pharmacogn 31: 163-167
  10. Kim TW, Song OK, Han SY, Cao QR, Park MJ, Kang SH, Sin KW, Cui JH, Lee BJ. 2005. Bioavailability of cefaclor capsules using an improved analytical method of cefaclor in human plasma. J Kor Pharm Sci 35: 117-122 https://doi.org/10.4333/KPS.2005.35.2.117
  11. Cho JY, Kim AR, Yeon JD, Lim SW, Lee JH, Yoo ES, Yu YH, Park MH. 1997. Effects of combined preparation (DWP715) containing Alaska pollack extract, maltol, ascorbic acid and nicotinamide on decreasing of blood alcohol concentration, anti-fatigue and anti-oxidation. Korean J Food Sci Technol 29: 167-172
  12. Bergmeyer HU. 1974. Alcohol dehydrogenase. In Methods of Enzymatic Analysis. Academic Press, New York. Vol 2, p 428-429
  13. Tottmar SO, Petterson H, Kiessling KH. 1973. The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem J 135: 577-586 https://doi.org/10.1042/bj1350577a
  14. Castro GD, de Castro CR, Maciel ME, Fanelli SL. 2006. Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: Potential factors involved in alcohol drinking promotion of breast cancer. Toxicology 219: 208-219 https://doi.org/10.1016/j.tox.2005.11.019
  15. Bae JW. 1999. Effects of red-ginseng extract on pharmacokinetics of ethanol. J Ginseng Res 23: 172-175
  16. Umulis DM, Gurmen NM, Singh P, Fogler HS. 2005. A physiologically based model for ethanol and acetaldehyde metabolism in human beings. Alcohol 35: 3-12 https://doi.org/10.1016/j.alcohol.2004.11.004
  17. Helander A, Tottmar O. 1988. Effect of acute ethanol administration on human blood aldehyde dehydrogenase activity. Alcohol Clin Exp Res 12: 643-646 https://doi.org/10.1111/j.1530-0277.1988.tb00257.x
  18. Zakhari S. 2006. Overview: how is alcohol metabolized by the body? Alcohol Res Health 29: 245-254

Cited by

  1. Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats vol.32, pp.6, 2016, https://doi.org/10.9724/kfcs.2016.32.6.818
  2. Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague–Dawley rats vol.60, 2013, https://doi.org/10.1016/j.fct.2013.07.033