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눈꽃동충하초 물추출물이 흰쥐의 알코올대사에 미치는 영향

Effects of Paecilomyces tenuipes Water Extract on the Alcohol Metabolism of Rats

  • Kim, Ji-Myung (Dept. of Food and Nutritional Sciences, Hanbuk University) ;
  • Park, Jae-Hwan (Food Convergence Technology Division, Korea Food Research Institute) ;
  • Kim, Mi-Kyung (Dept. of Food and Nutritional Science, Ewha Womans University) ;
  • Chun, Hyang-Sook (Food Convergence Technology Division, Korea Food Research Institute)
  • 발행 : 2008.03.31

초록

본 연구에서는 눈꽃동충하초 물추출물이 알코올 대사에 미치는 효과를 동물실험을 통하여 살펴보았다. 알코올과 그 대사산물인 아세트알데히드의 혈중 농도를 측정한 결과, 눈꽃동충하초 물추출물의 경구투여는 흰쥐의 혈중 알코올 농도에는 영향을 미치지 않았으나, 3, 6, 9시간째의 혈중 아세트알데히드 농도를 유의적으로 감소시켰다. 특히 100 mg/kg 농도의 눈꽃동충하초 물추출물 투여 시 혈중 아세트알데히드의 농도-시간 곡선하 면적에서 유의적인 감소를 보였다. 반면에 알코올 투여 후 9시간째 측정한 간의 알코올 탈수소효소, 알데히드 탈수소효소, MEOS의 활성은 눈꽃동충하초 물추출물 투여에 따른 변화를 보이지 않았다. 종합적으로 눈꽃동충하초 물추출물은 혈중 알코올 농도에는 영향을 미치지 않으나 혈중 아세트알데히드 농도를 감소시키는 것으로 보인다. 눈꽃동충하초 물추출물이 혈중 아세트알데히드 수준을 낮추는 작용기전과 관련하여, 경시적인 알코올대사 효소활성의 변화와 간 손상 관련 지표 조사 등에 관한 추가적인 연구가 필요할 것으로 사료된다.

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피인용 문헌

  1. Effects of Gastrodiae rhizoma on the Liver Function and Alcohol Metabolism in Alcohol Treated Rats vol.32, pp.6, 2016, https://doi.org/10.9724/kfcs.2016.32.6.818
  2. Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague–Dawley rats vol.60, 2013, https://doi.org/10.1016/j.fct.2013.07.033