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Effect of Deep Sea Water on Cytochrome P450 1A1, Aromatase and MMP-9.

해양심층수의 cytochrome P450 1A1, aromatase 및 MMP-9 활성 억제 효과

  • Shon, Yun-Hee (Regional Innovation System, Intractable Disease Research Center) ;
  • Kim, Mee-Kyung (Regional Innovation System, Dongguk University) ;
  • Nam, Kyung-Soo (Regional Innovation System, Department of Pharmacology, College of Medicine, Dongguk University)
  • 손윤희 (동국대학교 지역연고산업진흥사업단, 난치병한양방치료연구소) ;
  • 김미경 (동국대학교 지역연고산업진흥사업단) ;
  • 남경수 (동국대학교 지역연고산업진흥사업단, 동국대학교 의과대학 약리학교실)
  • Published : 2008.04.30

Abstract

Deep sea water from the East sea was tested for breast cancer chemoprevention and metastasis by measuring the activities of cytochrome P450 1A1 and aromatase, invasiveness, and activity and expression of matrix metalloproteinase (MMP)-9 in breast MDA-MB-231 cancer cell. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of $100{\sim}1,000$) showed a hardness-dependent inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced cytochrome P450 1A1 activity. Deep sea water showed 27.1, 45.4 and 51.9% inhibition of microsomal aromatase activity at the hardness of 600, 800 and 1,000, respectively. In addition deep sea water inhibited not only the invasiveness of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MDA-MB-231 cells through matrigel-coated membrane in a hardness-dependent manner but also the activity and expression of MMP-9 in MDA-MB-231 cell.

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