Changes of Serum Adiponectin Levels in Murine Experimental Sparganosis

  • Yang, Hyun-Jong (Department of Parasitology and Ewha Global Challenge, Ewha Womans University, School of Medicine)
  • Published : 2008.06.30

Abstract

The weight gain phenomenon associated with sparganosis has been well documented and was first recognized in the 1960s. Many studies have been conducted regarding the plerocercoid growth factor in the larva of Spirometra mansoni. In the present study, we hypothesized that the weight gain may be affected by the adipocyte secreted hormones, i.e., adiponectin, which is secreted from the adipose tissues in case of tissue migrating parasitic infections. Specifically, we attempted to ascertain whether the serum levels of adiponectin change in murine sparganosis. However, serum adiponectin levels assayed by ELISA evidenced no significant changes after an experimental infection (P > 0.05). Finally, the weight gain phenomenon in mouse sparganosis is not associated with changes in adiponectin levels, and further investigations involving parasitic infection-induced weight gain remain necessary.

Keywords

References

  1. Cho SY, Bae J, Seo BS, Lee SH. Some aspects of human sparganosis in Korea. Korean J Parasitol 1975; 13: 60-77. https://doi.org/10.3347/kjp.1975.13.1.60
  2. Mueller JF. Parasite-induced weight gain in mice. Ann N Y Acad Sci 1963; 113: 217-233. https://doi.org/10.1111/j.1749-6632.1963.tb40667.x
  3. Phares K, Kubik J. The growth factor from plerocercoids of Spirometra mansonoides is both a growth hormone agonist and a cysteine proteinase. J Parasitol 1996; 82: 210-215.
  4. Kong Y, Chung YB, Cho SY, Choi SH, Kang SY. Characterization of three proteases of Spirometra mansoni plerocercoid. Parasitology 1994; 108: 359-368. https://doi.org/10.1017/S0031182000076204
  5. Kong Y, Kang SY, Kim SH, Chung YB, Cho SY. A neutral cysteine protease of Spirometra mansoni plerocercoid invoking an IgE response. Parasitology 1997; 114: 263-271. https://doi.org/10.1017/S0031182096008529
  6. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697- 10703.
  7. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83. https://doi.org/10.1006/bbrc.1999.0255
  8. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickon MR, Yen FT, Bihain BE, Lodish HF. Proteolytic cleavage production of 30 kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl 92 Korean J Parasitol. Vol. 46, No. 2: 91-93, June 2008 Adiponectin (ng / ml) 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2 0 0 2 4 8 12 13 Weeks after infection Fig. 2. Serum adiponectin levels in murine experimental sparganosis. No significant changes between the normal and sparganuminfected groups were observed (P > 0.05). , normal control; , sparganum-infected group.Acad Sci USA 2001; 98: 2005-2010. https://doi.org/10.1073/pnas.041591798
  9. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50: 1511-1525. https://doi.org/10.1373/clinchem.2004.032482
  10. Das UN. Is obesity an inflammatory condition? Nutrition 2001; 17: 953-966. https://doi.org/10.1016/S0899-9007(01)00672-4
  11. Festa A, D'Agostino R Jr, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001; 25: 1407-1415. https://doi.org/10.1038/sj.ijo.0801792
  12. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972-978. https://doi.org/10.1161/01.ATV.19.4.972
  13. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, Miller GJ, Strachan DP. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis 2000; 149: 139-150. https://doi.org/10.1016/S0021-9150(99)00312-3
  14. Bouwman JJ, Visseren FL, Bouter KP, Diepersloot RJ. Infectioninduced inflammatory response of adipocytes in vitro. Int J Obes (Lond) 2008; [Epub ahead of print].
  15. Rikihisa Y, Lin YC, Fukaya T. Taenia taeniaeformis: inhibition of rat testosterone production by excretory-secretory product of the cultured metacestode. Exp Parasitol 1985; 59: 390-397. https://doi.org/10.1016/0014-4894(85)90094-3
  16. Yang HJ. Feminization and reduction of testicular weight in mouse sparganosis. Korean J Parasitol 2006; 44: 167-169. https://doi.org/10.3347/kjp.2006.44.2.167