Antibacterial, antioxidant and antitumor activities of mushroom mycelium mixed culture extracts

버섯 균사체 혼합 배양 추출물의 항균, 항산화 및 항암 활성

  • Kim, Man-Cheol (Faculty of marine science and Marine and environment institute, Cheju National University) ;
  • Kim, Ju-Sang (Faculty of marine science and Marine and environment institute, Cheju National University) ;
  • Heo, Moon-Soo (Faculty of marine science and Marine and environment institute, Cheju National University)
  • 김만철 (제주대학교 해양과학대학 해양과학부) ;
  • 김주상 (제주대학교 해양과학대학 해양과학부) ;
  • 허문수 (제주대학교 해양과학대학 해양과 환경연구소)
  • Published : 2008.04.29


In this study, we have investigated the antibacterial, antioxidant, and antitumor activities of mycelium cultural extract from mushroom. Mushroom mycelium was grown in a synthetic liquid media such as PD broth, YM broth or citrus extracts. In antibacterial activity test, the best result was achieved when mycelium cultural extracts from Phellinus linteus and Coriolus versicolor were incubated together on YM broth. On the other hand, mushroom mycelium cultured on citrus extracts showed better activity than that on PD broth. We have also tested the antioxidant activity at concentration up to 10 mg of mycelium cultural extract/mL. The more it is in higher concentration, the more the activity increases. The higher antioxidant activity was observed both on PD broth containing the Phellinus linteus and Coriolus versicolor mycelium and citrus extract containing the same. The complex culture extracts obtained from the synthetic medium and citrus extract medium showed 10-89% of the 1,1-diphenyl-2-picrylhydrazyl radical scavenger activity. The antitumor activity of mycelium cultural extract was examined by using MTT assay on A549 cells. Mushroom mycelium cultured on citrus extracts showed interestingly higher antitumor activity than that on synthetic liquid media.


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