Hepatic Protective Effect and Single-dose Toxicity Study of Water Extract of Cordyceps militaris Grown upon Protaetia dreujtarsis

굼벵이 유래 밀리타리스 동충하초 열수추출물의 간기능개선 효과 및 단회독성 평가

  • Jo, Wol-Soon (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Nam, Byung-Hyouk (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Oh, Su-Jung (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Choi, Yoo-Jin (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Kang, Eun-Young (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Hong, Sook-Hee (Dong-A University Medical Science Research Center, Clinical Research Center) ;
  • Lee, Sang-Ho (Seogwipo Agricultral Technique Center) ;
  • Jeong, Min-Ho (Dong-A University Medical Science Research Center, Clinical Research Center)
  • 조월순 (동아대학교병원 임상시험연구센터) ;
  • 남병혁 (동아대학교병원 임상시험연구센터) ;
  • 오수정 (동아대학교병원 임상시험연구센터) ;
  • 최유진 (동아대학교병원 임상시험연구센터) ;
  • 강은영 (동아대학교병원 임상시험연구센터) ;
  • 홍숙희 (동아대학교병원 임상시험연구센터) ;
  • 이상호 (서귀포시 농업기술센터) ;
  • 정민호 (동아대학교병원 임상시험연구센터)
  • Published : 2008.02.28


This study was designed to evaluate the single dose toxicity and the protective effect of water extract of Cordyceps militaris grown upon Protaetia dreujtarsis (CMPD extract) on liver damage on carbon tetrachloride ($CCl_4$)- induced acute hepatotoxicity in Sprague-Dawley (SD) rats. The CMPD extract was once administered orally to both sexes of rats at dose of 2,000, 1,000 and 500 mg/kg body weight, the recommended maximum limit dose for acute toxicity. Neither significant toxic signs nor death was observed during the observation period. These results indicate that $LD_{50}$(lethal dose of 50%) of CMPD extract is greater than 2,000 mg/kg body weight in SD rats. To investigate also the effect of hepatoprotection of CMPD extract, SD rats were orally treated with CMPD extract (50, 25 and 12.5 mg/kg body weight) or silymarin (25 mg/kg body weight) before and after administration of $CCl_4$ (2 mL/kg body weight, 20% $CCl_4$ in olive oil). Treatment with CMPD extract or silymarin could decrease the GPT (glutamic-pyruvic transaminase) and GOT (glutamic-oxaloacetic transaminase) levels in serum when compared with $CCl_4$-treated group. Therefore, the results of this study show that CMPD extract can be proposed to protect the liver against $CCl_4$-induced hepatic damage in rats.


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