Application of Oral Acute Toxic Class Method and Globally Harmonized Classification System on Pesticide

국내에서 농약에 대한 급성경구독성등급법 적용 및 GHS 체계 도입 제안

  • Jeong, Mi-Hye (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • You, Are-Sun (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • Park, Kyung-Hun (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • Kim, Byung-Seok (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • Lee, Hee-Dong (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • Lee, Jae-Bong (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA)) ;
  • Kwon, Oh-Kyung (Department of Crop Life Safety, National Institute of Agricultural Science and Technology (NIAST), Rural Development Administration (RDA))
  • 정미혜 (농업과학기술원 농산물안전성부) ;
  • 유아선 (농업과학기술원 농산물안전성부) ;
  • 박경훈 (농업과학기술원 농산물안전성부) ;
  • 김병석 (농업과학기술원 농산물안전성부) ;
  • 이희동 (농업과학기술원 농산물안전성부) ;
  • 이제봉 (농업과학기술원 농산물안전성부) ;
  • 권오경 (농업과학기술원 농산물안전성부)
  • Published : 2008.06.30

Abstract

Globally Harmonized System (GHS) for classification and labelling will provide an internationally agreed hazard classification system of chemical products and for communication of those hazards. This study aimed for establishment of the oral acute toxic class (ATC) method and application of GHS on pesticides. The ATC method was developed for determining $LD_{50}$ estimates of chemical substances with significantly fewer animals than needed when applying conventional $LD_{50}$ tests. We carried out $LD_{50}$ test and ATC test on 13 pesticides, Although methidathion EC and parathion-ethyl EC showed significantly different in $LD_{50}$ values between $LD_{50}$ test and ATC method, there are no difference in toxicity class by GHS. Both tests on the other pesticides showed almost equal results and toxicity class by GHS. Therefore, this study indicated high possibility of application of ATC method and GHS on pesticides.

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