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A Study on the Effect of Herbal-acupuncture with HK-1000 Solution on Hyperlipidemia and Arteriosclerosis Induced Rats

HK-1000 약침이 흰쥐의 고지혈증 및 동맥경화증에 미치는 영향

  • Park, Chi-Young (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Hong, Kwon-Eui (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University)
  • 박치영 (대전대학교 한의과대학 침구학교실) ;
  • 홍권의 (대전대학교 한의과대학 침구학교실)
  • Published : 2008.09.30

Abstract

Objective&Methods: The purpose of this study is to observe the effects of HK-1000 Herbal-acupuncture solution at GB34(Yangleungchean) on hyperlipidemia and arteriosclerosis in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological change of liver and aorta. Results: 1. HK-1000 herbal-acupuncture infusion increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI(atherogenic index) were decreased, and the ratio of HDL to TCL(HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1000 group, serum AST and ALT were significantly lower than those of the HG group and saline group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusions: From the above results, it is suggested that HK-1000 herbal-acupuncture at GB34 has a therapeutic effect on hyperlipidemia and arteriosclerosis.

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