Inhibition Effect of 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)Propionic Acid in Kimchi with Anti-Atherogenic Activity on the Accumulation of Lipids in the Organs of ApoE(-/-) Mice

ApoE(-/-) Mice에서 배추김치 활성 성분인 3-(4'-hydroxyl-3',5'-dimethoxylphenyl)Propionic Acid의 장기 지질저하 효과

  • Kim, Hye-Yeon (Dept. of Food Science & Nutrition, and Kimchi Research Institute, Pusan National University) ;
  • Noh, Jeong-Sook (Dept. of Food Science & Nutrition, and Kimchi Research Institute, Pusan National University) ;
  • Song, Yeong-Ok (Dept. of Food Science & Nutrition, and Kimchi Research Institute, Pusan National University)
  • 김혜연 (부산대학교 생활환경대학 식품영양학과 및 김치연구소) ;
  • 노정숙 (부산대학교 생활환경대학 식품영양학과 및 김치연구소) ;
  • 송영옥 (부산대학교 생활환경대학 식품영양학과 및 김치연구소)
  • Published : 2008.11.28


Preventive effects of 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), an active compound in Korean cabbage kimchi with anti-atherogenic effects, on the accumulation of lipids in the vital organs of $apoE^{(-/-)}$ mice fed atherogenic diet (AD) were studied. Each group of 10 mice was fed AD for 8 weeks with intraperitoneal injection of either HDMPPA (1 mg HDMPPA/100 g BW/day) or phosphate buffered saline as a vehicle. The organs used for this study were liver, kidney, spleen, lung, testis, and brain. Total cholesterol (TC) concentration of lung was the highest followed by spleen and brain. TC level for the liver was the lowest. In contrast to the results of TC, triglyceride (TG) concentration in the liver was the highest followed by kidney and testis. $ApoE^{(-/-)}$ mice did not have any problem uptaking chylomicron remnant by the liver which carries an extra TG after delivering it to the adipose tissue. HDMPPA retarded TC and TG accumulations in the vital organs. Thiobarbituric acid reactive substances (TBARS) in the brain and spleen were the highest and that in the testis were the lowest. Poly-unsaturated fatty acids in the brain and activated peroxisome in the spleen might be responsible for high TBARS levels in these organs. The greatest antioxidant effect of HDMPPA against lipid peroxidation was observed in the spleen, showing 21.47% decrease. The most noticeable effect of HDMPPA was observed in glutathione (GSH) level. GSH levels of six organs in the HDMPPA group were significantly higher than those of the control group. GSH-peroxidase activity was negatively related to GSH level of the organs except liver and spleen. In conclusion, HDMPPA from Korean cabbage kimchi inhibits the lipid accumulation as well as increases the antioxidant status in the vital organs of $apoE^{(-/-)}$ mice fed an atherogenic diet.


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