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A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines

친환경적 One Pot 합성, In Vitro에서 Morpholino Pyrimidines의 분광학적 특성과 항균성 및 항진균성

  • Kanagarajan, V. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University) ;
  • Thanusu, J. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University) ;
  • Gopalakrishnan, M. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University)
  • Published : 2009.12.20

Abstract

‘One-pot’ reaction procedure for the synthesis of novel morpholino pyrimidines (10-18) under microwave irradiation in ‘dry media’ in the presence of heterogeneous $NaHSO_4.SiO_2$ catalyst was developed. All the synthesized compounds were screened for their in vitro antibacterial activities against clinically isolated bacterial strains namely Bacillus subtilis, Bacillus cerues, Micrococcus luteus and Salmonella typhii and antifungal activities against fungal strains namely Aspergillus niger, Candida 6 and Candida 51. Structure activity relationship of the synthesized compounds against microbiological results was discussed.

Keywords

‘One-pot’ synthesis;(E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones;Morpholino pyrimidines;Antibacterial activities;Antifungal activities

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