DOI QR코드

DOI QR Code

친환경적 One Pot 합성, In Vitro에서 Morpholino Pyrimidines의 분광학적 특성과 항균성 및 항진균성

A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines

  • Kanagarajan, V. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University) ;
  • Thanusu, J. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University) ;
  • Gopalakrishnan, M. (Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University)
  • 발행 : 2009.12.20

초록

$NaHSO_4.SiO_2$ 촉매를 이용한 microwave 및 무수조건하에서 새로운 morpholino pyrimidines의 One-pot합성이다. 합성된 모든 화합물을 이용하여 in vitro에서 임상학적인 단리된 박테리아 품종 즉 Bacillus subtilis, Bacillus cerues, Micrococcus luteus , Salmonella typhii에 대해 항균성을 살펴보았고, 균품종 즉 Aspergillus niger, Candida 6, Candida 51에 대해 항진균성을 살펴보았다. 미생물 결과에 대한 합성된 화합물의 구조적 활동성의 관련성에 대해 토론하였다.

키워드

‘One-pot’ 합성;항균성;항진균성

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