Biomechanical Characterization with Inverse FE Model Parameter Estimation: Macro and Micro Applications

유한요소 모델 변수의 역 추정법을 이용한 생체의 물성 규명

  • 안범모 (한국과학기술원 기계공학과) ;
  • 김영진 (한국과학기술원 기계공학과) ;
  • 신현정 (한국과학기술원 기계공학과) ;
  • 김정 (한국과학기술원 기계공학과)
  • Published : 2009.11.01


An inverse finite element (FE) model parameter estimation algorithm can be used to characterize mechanical properties of biological tissues. Using this algorithm, we can consider the influence of material nonlinearity, contact mechanics, complex boundary conditions, and geometrical constraints in the modeling. In this study, biomechanical experiments on macro and micro samples are conducted and characterized with the developed algorithm. Macro scale experiments were performed to measure the force response of porcine livers against mechanical loadings using one-dimensional indentation device. The force response of the human liver cancer cells was also measured by the atomic force microscope (AFM). The mechanical behavior of porcine livers (macro) and human liver cancer cells (micro) were characterized with the algorithm via hyperelastic and linear viscoelastic models. The developed models are suitable for computing accurate reaction force on tools and deformation of biomechanical tissues.


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