Evaluation of Stability in the Purified Wood Vinegar and Its Hair Growth Effect

목초액의 안정성 및 모발 성장 촉진 효과

  • Cho, Young-Ho (Department of Pharmaceutical Engineering, Konynag University) ;
  • Lee, Ju-Yeon (Department of medical Beauty, Konyang University) ;
  • Lee, Jong-Hwa (Division of Research and Development, Korea Institute of Toxicology) ;
  • Cho, Jae-Su (Department of Pharmaceutical Engineering, Konynag University) ;
  • Lee, Gye-Won (Department of Pharmaceutical Engineering, Konynag University)
  • 조영호 (건양대학교 제약공학과) ;
  • 이주연 (건양대학교 의료 뷰티학과) ;
  • 이종화 (한국화학연구원 안전성평가연구소) ;
  • 조재수 (건양대학교 제약공학과) ;
  • 이계원 (건양대학교 제약공학과)
  • Published : 2009.10.30


Generally, it takes a long time to purify wood vinegar, and it contains toxic compounds such as tar, methanol, phenol and benzopyrene. To reduce the toxicity of wood vinegar itself, we have developed a new purification method of wood vinegar using an oxidation-cohesion reaction and distillation with an active carbon. We have investigated the physico-chemical change (pH, specific gravity, refractive index and dissolved tar), the change of amount of toxic compounds (carbonyl group, phenol, benzopyrene and residual solvents) and organic acids (formic acid (FA), acetic acid (AA), propionic acid (PA)) of the purified wood vinegar under the long term and accelerated storage conditions. Also, we have evaluated the effect of the purified wood vinegar on hair growth using an alopecia model of C57BL/6 mice. As a result, we could find out that the purified wood vinegar was stable and remained without decay under the storage conditions and benzopyrene, a carcinogenic agent, was not detected in the purified wood vinegar. After topical treatment of the purified wood vinegar solution or minoxidil (MXD) for 2 weeks to dorsal skin, the hair regrowth of the mice accelerated faster than that of the control, with no clinical signs. In conclusion, we could suggest a guideline for quality control of process to reduce the toxic compounds in wood vinegar and it might be a useful hair growth promoter in the treatment of baldness or alopecia.


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