Analysis of Flumeqnine in Meats

식육 중 항생제 flumequine의 분석

  • Kuk, Ju-Hee (Gwangju Regional Korea Food and Drug Administration) ;
  • Ko, Yong-Seok (Gwangju Regional Korea Food and Drug Administration) ;
  • Kim, Yong-Hoon (Seoul Regional Korea Food and Drug Administration) ;
  • Yoon, Chang-Yong (National Institute of Toxicological Research) ;
  • Sun, Nam-Kyu (Daejeon Regional Korea Food and Drug Administration) ;
  • Kim, Eun-Jung (Gwangju Regional Korea Food and Drug Administration) ;
  • Seo, Jee-Woo (Gwangju Regional Korea Food and Drug Administration) ;
  • Park, Ji-Won (Gwangju Regional Korea Food and Drug Administration) ;
  • Kang, Kil-Jin (Korea Food and Drug Administration)
  • 국주희 (광주지방식품의약품안전청) ;
  • 고용석 (광주지방식품의약품안전청) ;
  • 김용훈 (서울지방식품의약품안전청) ;
  • 윤창용 (국립독성과학원) ;
  • 선남규 (대전지방식품의약품안전청) ;
  • 김은정 (광주지방식품의약품안전청) ;
  • 서지우 (광주지방식품의약품안전청) ;
  • 박지원 (광주지방식품의약품안전청) ;
  • 강길진 (식품의약품안전청 영양기능식품국)
  • Published : 2009.02.28


An analytical method for the determination of flumequine in meats was developed and validated using high-performance liquid chromatography with fluorescence detection. The samples were mixed with sodium sulfate and extracted with ethyl acetate. After clean-up, the residues were dissolved in mobile phase. The calibration curves showed high linearity ($r^2$=0.9979) within the concentration range of 0.1-1.0 mg/kg. The limit of detection and limit of quantification were validated at 0.005 and 0.017 mg/kg, respectively. The recoveries in fortified meats ranged from 90.8 to 101.1%. The method was then validated in correspondence with the CODEX guidelines for flumequine residue in meats. Herein we monitored 150 samples of meats that were purchased in Korea (Seoul, Busan, Daegu, Daejeon, and Gwangju). Among the tested samples, flumequine was detected in 1 of beef and 1 of pork at levels in the range of 0.048-0.080 mg/kg. Overall, the flumequine residues in the tested samples were within the Maximun residue limit.


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