Histological Study of Extraction Socket Grafted with Calcium Phosphate Materials: An Animal Study

Calcium Phosphate Graft Material이 적용된 발치와의 치유 양상에 대한 조직학적 연구

  • Yang, Seung-Min (Department of Periodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yoon, Hyun-Min (Department of Periodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Seung-Yoon (Department of Periodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kye, Seung-Beom (Department of Periodontics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 양승민 (성균관대학교 의과대학 삼성서울병원 치과진료부 치주과) ;
  • 윤현민 (성균관대학교 의과대학 삼성서울병원 치과진료부 치주과) ;
  • 신승윤 (성균관대학교 의과대학 삼성서울병원 치과진료부 치주과) ;
  • 계승범 (성균관대학교 의과대학 삼성서울병원 치과진료부 치주과)
  • Received : 2009.08.05
  • Accepted : 2009.09.25
  • Published : 2009.09.30


The purpose of this study was to evaluate histologic result of bone substituting materials on extraction sockets. We compare the histologic findings of control, $MBCP^{(R)}$, $Polybone^{(R)}$. Mandibular premolar teeth of Beagle dogs were extracted available for bone filling. All alveolar extraction sockets were thoroughly debrided with surgical curet to remove the periodontal ligament. The graft materials were filled into the extraction sockets. The animals were sacrified 90 days after implantation. Both treated and control mandibular sites were histologically evaluated with light microscopy. Histological observation at 90 days revealed that control and experimental sites were healed uneventfully without any adverse tissue reaction. Regenerated new bone formation ratio is 34.5% for control, 28.4% for $MBCP^{(R)}$, 23.8% for $Polybone^{(R)}$. From this results, it was suggested that $MBCP^{(R)}$, $Polybone^{(R)}$ are promising bone substituting materials to promote normal tissue healing and new bone formation.


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