Myogenic Satellite Cells and Its Application in Animals - A Review

  • Singh, N.K. (Stem Cell Culture and Molecular Orthopaedic Laboratory, Division of Surgery, F.V.S.c & A.H, SKUAST-J, R.S.) ;
  • Lee, H.J. (Nutrition and Physiology, NLRI) ;
  • Jeong, D.K. (Dept. Animal Biotechnology, College of Applied Life Science, Jeju National University) ;
  • Arun, H.S. (Center for Research in Vascular biology, University of cork) ;
  • Sharma, L. (Stem Cell Culture and Molecular Orthopaedic Laboratory, Division of Surgery, F.V.S.c & A.H, SKUAST-J, R.S.) ;
  • Hwang, I.H. (Stem Cell Culture and Molecular Orthopaedic Laboratory, Division of Surgery, F.V.S.c & A.H, SKUAST-J, R.S.)
  • Received : 2009.01.14
  • Accepted : 2009.04.22
  • Published : 2009.10.01


Myogenic satellite cells have been isolated and identified by several recently elucidated molecular markers. Furthermore, knowledge about the precise function of these markers has provided insight into the early and terminal events of satellite cells during proliferation, differentiation, transdifferentiation, specification and activation. Recently, quiescent myogenic satellite cells have been associated with possession of Pax 3 and 7 that represent pluripotent stem cells capable of differentiating into other lineages. However, the mechanism by which myogenic satellite cells attain pluripotent potential remain elusive. Later, transdifferentiating ability of these cells to another lineage in the absence or presence of certain growth factor/ or agents has revolutionized the scope of these pluripotent myogenic satellite cells for manipulation of animal production (in terms of quality and quantity of muscle protein) and health (in terms of repair of skeletal muscle, cartilage or bone).


Satellite Cells;Myogenesis;Plasticity;Transdifferentiation;Adipogenesis


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