The Effect of Temperature and Concentration of Setting Solution on the Rheological Properties of Injectable Calcium Phosphate

경화액의 농도와 온도가 인산칼슘시멘트의 유변학적 성질에 미치는 영향에 관한 연구

  • Yoo, Hyun-Mi (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University, School of Medicine) ;
  • Chang, Seok-Woo (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University, School of Medicine) ;
  • Park, Dong-Sung (Department of Conservative Dentistry, The institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University, School of Medicine)
  • 유현미 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 장석우 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과) ;
  • 박동성 (성균관대학교 의과대학 삼성서울병원 치과진료부 보존과)
  • Received : 2008.12.16
  • Accepted : 2009.03.25
  • Published : 2009.03.31

Abstract

Injectable calcium phosphate cement (CPC) has been used as bone substitute successfully due to good biocompatibility and osteoconductivity. One of the important mechanical characteristics of CPC is flowablility, which can be evaluated by measuring rheological parameters. However, there have been few studies that measured rheological properties of CPC. The purpose of this study was to evaluate the effects of temperature and concentrations of 2 kinds of setting solutions, hydroxyprophyl methylcellulose (HPMC) and polyacrylic acid (PAA), on rheological properties of CPC. The CPC used was dicalcium phosphate dihydrate (DCPD). Rheological properties of CPC paste were measured using rheometer. The effect of concentrations of each solution (2% and 1% HPMC and 35% and 17.5% PAA) was evaluated. The effect of temperature ($25^{\circ}C$ and $37^{\circ}C$) on the rheological properties of CPC was also investigated. The statistical analysis was carried out with Mann-whitney test with Bonferronis collection. CPC with both setting solutions showed shear thinning behavior. Higher concentrations of setting solution (2% HPMC and 35% PAA) produced significantly higher viscosity than lower concentrations of setting solution (1% HPMC and 17.5% PAA). CPC with HPMC showed significantly higher viscosity at $37^{\circ}C$ that at $25^{\circ}C$. CPC with PAA showed lower viscosity at $37^{\circ}C$ than at $25^{\circ}C$, although the difference was not statistically significant. The results showed that CPC with HPMC or PAA solutions are pseudoplastic and the concentrations of setting solutions and temperature may have an effect on the rheological properties of CPC paste. These results showed that the flowability of injectable CPC could be improved by use of increasing frequency of oscillation. In clinical practice, the use of ultrasonic vibration would be helpful in application of injectable CPC. CPC with HPMC could be more easily applicated at $25^{\circ}C$ than $37^{\circ}C$. The use of lower concentrations of HPMC and PAA solution would be beneficial in terms of flowability.

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