Removal Torque of Mg-ion Implanted Clinical Implants with Plasma Source Ion Implantation Method

마그네슘 이온주입 임플란트의 뒤틀림 제거력에 관한 연구

  • Kim, Bo-Hyoun (Dept. of Prosthodontics & Research Institute of Oral Science, College of Dentistry, National University of Kangnung-Wonju) ;
  • Kim, Dae-Gon (Dept. of Prosthodontics & Research Institute of Oral Science, College of Dentistry, National University of Kangnung-Wonju) ;
  • Park, Chan-Jin (Dept. of Prosthodontics & Research Institute of Oral Science, College of Dentistry, National University of Kangnung-Wonju) ;
  • Cho, Lee-Ra (Dept. of Prosthodontics & Research Institute of Oral Science, College of Dentistry, National University of Kangnung-Wonju)
  • 김보현 (강릉원주대학교 치과대학 보철학교실 및 구강과학연구소) ;
  • 김대곤 (강릉원주대학교 치과대학 보철학교실 및 구강과학연구소) ;
  • 박찬진 (강릉원주대학교 치과대학 보철학교실 및 구강과학연구소) ;
  • 조리라 (강릉원주대학교 치과대학 보철학교실 및 구강과학연구소)
  • Received : 2009.01.20
  • Accepted : 2009.03.25
  • Published : 2009.03.31

Abstract

The surface treatment of titanium implant could bring out the biochemical bonding between bone and implant. The purpose of this study was to evaluate the biomechanical bone response of Mg-ion implanted implants with plasma source ion implantation method. Twelve New Zealand white rabbits were included in this study. Each rabbit received one control fixture (blasted with resorbable blasting media, RBM) and three types of Mg ion implanted fixtures in tibiae. The implants were left in place for 6 weeks before the rabbits were sacrificed. Removal torque value and resonance frequency analysis (ISQ) were compared. The repeated measured analysis of variance was used with $P{\leq}0.05$ as level of statistical significance. ISQ was not different among all groups. However, the ISQ was increased after 6 weeks healing. The group had lowest ISQ value showed the greatest increment. Mg-1 implants with 9.4% retained ion dose showed significantly higher removal torque value than that of the other implants. From this results, it is concluded that the Mg-1 implants has stronger bone response than control RBM surface implant.

References

  1. Sul YT, Johansson CB, Jeong Y, Wennerberg A, Albrektsson T. Resonance frequency and removal torque analysis of implants with turned and anodized surface oxides. Clin Oral Implants Res 2002;13:252-259 https://doi.org/10.1034/j.1600-0501.2002.130304.x
  2. Ellingsen JE, Johansson CB, Wennerberg A, Holmen A. Improved retention and bone-to-implant contact with fluoride-modified titanium implants. Int J Oral Maxillofac Implants 2004;19:659-666
  3. Maitz MF, Poon RW, Liu XY, Pham MT, Chu PK. Bioactivity of titanium following sodium plasma immersion ion implantation and deposition. Biomaterials. 2005; 26:5465-5473 https://doi.org/10.1016/j.biomaterials.2005.02.006
  4. Johansson C, Lausmaa J, Rostlund T, Thomsen P. Commercially pure titamium and Ti6Al4V implants with and without nigrogen ion-implantation: surface characterization and quantitative studies in rabbit cortical bone. J Mater Sci-Mater Med 1993;4: 132-141 https://doi.org/10.1007/BF00120382
  5. Mändl S, Krause D, Thorwarth G, Sader R, Zeihofer F, Horch HH, Rauschenbach B. Plasma immersion ion implantation treatment of medical implants. Surf Coat Tech 2001; 142:1046-1050 https://doi.org/10.1016/S0257-8972(01)01066-0
  6. Mould AP, Akiyama SK, Humphries MJ. Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+,Mg2+,andCa2+.JBiolChem 1996;270:26270-26277 https://doi.org/10.1074/jbc.270.44.26270
  7. Meredith N. Assessment of implant stability as a prognostic determinant. Int J Prosthodont 1998;11: 491-501
  8. Sennerby, L., Thomsen, P. & Ericson, L.E. Ultrastructure of the bone–titanium interface in rabbits. Journal of Materials Science: Materials in Medicine 1992;3:262–271 https://doi.org/10.1007/BF00705291
  9. Kim HM, Miyaji F, Kokubo T, Nakamura T. Preparation of bioactive Ti and its alloys via simple chemical surface treatment. J Biomed Mater Res. 1996 ;32:409-417 https://doi.org/10.1002/(SICI)1097-4636(199611)32:3<409::AID-JBM14>3.0.CO;2-B
  10. Howlett CR, Zreiqat H, Odell R, Noorman J, Evan P, DaltonBA, Mcfarland C, Steele JG.The effect of magnesium ion implantation into alumina upon the adhesion of human bone-derived cells. J Mater Sci-Mater Med 1994;5:715-722 https://doi.org/10.1007/BF00120363
  11. Zreiqat H, Howlett CR, Zannettino A, Evans P, Schulze-Tanzil G, Knabe C, Shakibaei M. Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants. J Biomed Mater Res 2002;62:175-184 https://doi.org/10.1002/jbm.10270
  12. Friberg, B., Sennerby, L., Linde'n, B., Grondahl, K. & Lekholm,U. Stability measurements of one-stage Branemark implants during healing in mandibles. A clinical resonance frequency study. Int J Oral Maxillofac Surg 1999:28;266–272 https://doi.org/10.1016/S0901-5027(99)80156-8
  13. Hanawa T, Kamiura Y, Yamamoto S, Kohgo T, Amemiya A, Ukai H, Murakami K, Asaoka K. Early bone formation around calcium-ion-implanted titanium inserted into rat tibia. J Biomed Mater Res 1997;36:131-136 https://doi.org/10.1002/(SICI)1097-4636(199707)36:1<131::AID-JBM16>3.0.CO;2-L
  14. Sul YT, Johansson P, Chang BS, Jeong BY. Bone tissue responses to Mg-incorporated oxidized implants and machine-turned implants in the rabbit femur. J of appl Biomaterials and Biomechanics 2005;3:18-28
  15. Mueller WD, Gross U, Fritz T, Voigt C, Fischer P, Berger G. Evaluation of the interface between bone and titanium surfaces being blasted by aluminium oxide or bioceramic particles. Clin Oral Implants Res 2003;3:349-356
  16. Trisi P, Lazzara R, Rebaudi A, Rao W, Testori T, Porter SS. Bone-implant contact on machined and dual acid-etched surfaces after 2 months of healing in the human maxilla. J Periodontol 2003;74:945–956 https://doi.org/10.1902/jop.2003.74.7.945
  17. Sawase T, Wennerberg A, Baba K, Tsuboi Y, Sennerby L, Johansson CB, Albrektsson T.Application of oxygen ion implantation to titanium surfaces: effects on surface characteristics, corrosion resistance, and bone response.Clin Implant Dent Relat Res. 2001;3:221-229 https://doi.org/10.1111/j.1708-8208.2001.tb00144.x
  18. Wennerberg A, Albrektsson T, Albrektsson B, Krol JJ. Histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topographies. Clin Oral Implant Res 1996; 6:24–30 https://doi.org/10.1034/j.1600-0501.1995.060103.x
  19. Norman GR, Streiner DL. Biostatistics, The bare essentials. Mosby. St. Louis, 1994. Chap. 11 repeated-Measures ANOVA. 88-94
  20. Parise LV, Phillips DR. Fibronectin-binding properties of the purified platelet glycoprotein Ⅱb-Ⅲa comples. J Biol Chem 1986;261:14011-14017
  21. Krause A, Cowles EA, Gronowicz G. Integrin- mediated signaling in osteoblasts on titanium implant materials. J Biomed Mater Res 2000;52:738-747 https://doi.org/10.1002/1097-4636(20001215)52:4<738::AID-JBM19>3.0.CO;2-F
  22. Gailit J, Ruoslahti E. Regulation of the fibronectin receptor affinity by divalent cations. J Biol Chem 1988;263:12927-12932
  23. Byon E, Moon S, Cho S, Jeong C, Jeong Y, Sul YT. Electrochemical property and apatite formation of metal ion implanted titanium for medical implants Surf. Coat. Technol. 2005; 200: 1018-1021 https://doi.org/10.1016/j.surfcoat.2005.02.133
  24. Martin JY, Schwartz Z, Hummert TW, Schraub DM, Simpson J, Lankford J, Dean DD, Cochran D, Boyan BD. Effect of titanium surface-roughness on proliferation, differentiation, and protein-synthesis of human osteoblast-like cells(MG63). J Biomed Mater Res 1995;29:389-401 https://doi.org/10.1002/jbm.820290314
  25. Albrektsson T, Wennerberg A. The impact of oral implants - past and future. 1966-2042 J Can Dent Assoc 2005;71:327
  26. Piatelli M, Scarano A, Paolantonio M, Iezzi G, Petrone G, Piatelli A. Bone response to machined and resorbable blast material titanium implants: an experimental study in rabbits. J Oral Implantol 2002;28:2–88 https://doi.org/10.1563/1548-1336(2002)028<0002:BRTMAR>2.3.CO;2