Synergistic Effects of KH-red Ginseng/chlorella on the Endurance Capacity and Immune Enhancing in Forced Swimming Tested Mice

  • Choi, In-Young (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Lee, Ji-Hyun (Department of Pharmacology, College of Pharmacy, Wonkwang University) ;
  • Kang, Tae-Hee (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • An, Hyo-Jin (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Su-Jin (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Moon, Phil-Dong (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Na-Hyung (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Myung, Noh-Yil (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Yang, Deok-Chun (Department of Oriental Medicine Material and Processing, College of Life Science, Kyung Hee University) ;
  • Kang, In-Cheol (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Choi, Young-Jin (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim, Min-Ho (NUMATE of Chonbuk National University) ;
  • Um, Jae-Young (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (Department of Pharmacology, College of Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Biochip Research Center, Hoseo University)
  • Published : 2009.12.31

Abstract

KH-red ginseng/chlorella (KH-RG/C) is the mixed material of the Korean red ginseng powder (Panax ginseng, 75%) and extract of Chlorella vulgaris (25%). To evaluate the effects of KH-RG/C on endurance capacity and immune regulation, the forced swimming test (FST) was conducted. The immobility time in the FST was significantly decreased in KH-RG/C treated group compared with the DW-treated group at the 3 and 10 days, respectively. In the analysis of the blood biochemical parameters, KH-RG/C treatment significantly increased the glucose level. However, the lactic dehydrogenase level decreased. Although KH-RG/C increased aspartate aminotransferase, it was not different significantly. And KH-RG/C had no affects in the alanine aminotransferase, and blood urea nitrogen levels. In splenocytes and macrophages, KH-RG/C also did not affect the interleukin (IL)-2, IL-4, and IL-12 production. These results suggest that KH-RG/C may influence to immune regulation through increasing the physical endurance capacity without effect in activation of immune cells.

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