Topical Application of Clonazepam to Burning Mouth Syndrome

구강 작열감 증후군에서 클로나제팜의 국소적 적용

  • Shim, Young-Joo (Department of orofacial pain and oral medicine, College of Dentistry, Yonsei University) ;
  • Choi, Jong-Hoon (Department of orofacial pain and oral medicine, College of Dentistry, Yonsei University) ;
  • Ahn, Hyung-Joon (Department of orofacial pain and oral medicine, College of Dentistry, Yonsei University) ;
  • Kwon, Jeong-Seung (Department of orofacial pain and oral medicine, College of Dentistry, Yonsei University)
  • 심영주 (연세대학교 치과대학 구강내과학교실) ;
  • 최종훈 (연세대학교 치과대학 구강내과학교실) ;
  • 안형준 (연세대학교 치과대학 구강내과학교실) ;
  • 권정승 (연세대학교 치과대학 구강내과학교실)
  • Published : 2009.12.30

Abstract

Burning mouth syndrome (BMS) is defined as burning pain in the tongue or other oral mucous membrane associated with normal sign and laboratory findings at least 4 to 6 months. There are many factors that affect this condition and the pain characters are various among the sufferers, so it is difficult to diagnose exactly and treat properly. The cause of BMS is currently unknown. The etiology is presumed to be that it is related with local, systemic and psychogenic factor. The BMS is related with local factor such as allergic reaction, oral fungal infection(candidiasis), parafunctional oral habits and systemic factors such as diabetes mellitus, hypothyroidism, nutritional deficiencies(vitamin $B_{12}$, folic acid), hyposalivation and psychogenic factor such as depression, anxiety, cancerphobia. So clinicians must be aware of these factors and can give proper treatment options to patients. The management of BMS are pharmacologic management, cognitive behavioral therapy and psychotherapy treatment. Clonazepam, gabapentin, amitriptyline, alpha-lipoic acid and capsaicin are used to manage the BMS. Among these, topical clonazepam is reported that the effect is higher than systemic medication and the complications are rare. This case report is about some cases of the effect of topical clonazepam on BMS.

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