Effects of ${\alpha}$-Asarone against Global Cerebral Ischemia in Rats

  • Kim, Young-Ock (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration) ;
  • Kwon, Yong-Soo (Department of Pharmacy, College of Pharmacy, Kangwon National University) ;
  • Lee, Seong-Eun (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration) ;
  • Lee, Sang-Won (Herbal Crop Processing Research Team Department of Herbal Crop Research National Institute of Horticultural & Herbal Science Rural Development Administration) ;
  • Lee, Hee-Jae (Department of pharmacology, College of Medicine, Kangwon National University)
  • Published : 2009.12.31

Abstract

Based on the use of Acorus gramineus SOLAND (AG) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of ${\alpha}$-asarone after transient global cerebral ischemia using rat 4-vessel occlusion (4VO) model in rats. ${\alpha}$-Asarone (5 mg/kg) administered intraperitoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. ${\alpha}$-Asarone significantly reduced hippocampal neuronal cell death by 85.2% where as its isolated single compounds from AG compared with a vehicle-treated group.

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