DOI QR코드

DOI QR Code

Glucose Prediction in the Interstitial Fluid Based on Infrared Absorption Spectroscopy Using Multi-component Analysis

  • Kim, Hye-Jeong (Institute for Biomedical Electronics, Seoul National University of Technology) ;
  • Noh, In-Sup (Department of Chemical Engineering, Seoul National University of Technology) ;
  • Yoon, Gil-Won (Department of Electronics & Information Engineering, Seoul National University of Technology)
  • Received : 2008.04.23
  • Accepted : 2009.05.28
  • Published : 2009.06.25

Abstract

Prediction of glucose concentration in the interstitial fluid (ISF) based on mid-infrared absorption spectroscopy was examined at the glucose fundamental absorption band of 1000 - 1500/cm (10 - 6.67 um) using multi-component analysis. Simulated ISF samples were prepared by including four major ISF components. Sodium lactate had absorption spectra that interfere with those of glucose. The rest NaCl, KCl and $CaCl_2$ did not have any signatures. A preliminary experiment based on Design of Experiment, an optimization method, proved that sodium lactate influenced the prediction accuracy of glucose. For the main experiment, 54 samples were prepared whose glucose and sodium lactate concentration varied independently. A partial least squares regression (PLSR) analysis was used to build calibration models. The prediction accuracy was dependent on spectrum preprocessing methods, and Mean Centering produced the best results. Depending on calibration sample sets whose sodium lactate had different concentration levels, the standard error prediction (SEP) of glucose ranged $17.19{\sim}21.02\;mg/dl$.

References

  1. N. H. Jo, 'Prevalence of diabetes and management status in Korean population,' The Korea Journal of Internal Medicine 68, 10-17 (2005)
  2. R. McNichols and G. L. Cote, 'Optical glucose sensing in biological fluids : an overview,' J. Biomedical Optics 5, 5-16 (2000) https://doi.org/10.1117/1.429962
  3. S. H. Kim, D. S. Choi, and D. Kim, 'Single detection of fluorescence resonance energy transfer using confocal microscopy,' J. Opt. Soc. Korea 12, 107-111 (2008) https://doi.org/10.3807/JOSK.2008.12.2.107
  4. C. C. Byeon, M.-K. Oh, H. Kang, D.-K. Ko, and J. Lee, 'Coherent absorption spectroscopy with supercontinuun for semiconductor quantum well structure,' J. Opt. Soc. Korea 11, 138-141 (2007) https://doi.org/10.3807/JOSK.2007.11.3.138
  5. S. Mitragotri, M. Coleman, J. Kost, and R. Langer, 'Transdermal extraction of analytes using low-frequency ultrasound,' Pharmaceutical Research 4, 466-470 (2000) https://doi.org/10.1023/A:1007537222591
  6. H. K. Seong, Physiology (Medical culture co., Seoul, Korea, 1991), pp. 268-275
  7. N. Fogh-Andersen, B. M. Altura, B. T. Altura, and O. Siggaard-Andersen, 'Composition of interstitial fluid,' Clinical Chemistry 41, 1522-1525 (1995)
  8. A, Sieg, R. H. Guy, and M. B. Delgado-Charro, 'Noninvasive and minimally invasive methods for transdermal glucose monitoring,' Diabetes Technology & Therapeutics 7, 174-197 (2005) https://doi.org/10.1089/dia.2005.7.174
  9. H. Chung, M. A. Arnold, M. Rhiel, and D. W. Murhammer, 'Simultaneous measurements of glucose, glutamine, ammonia, lactate, and glutamate in aqueous solutions by near-infrared spectroscopy,' Applied Spectroscopy 50, 270-276 (1996) https://doi.org/10.1366/0003702963906447
  10. http://drugs-about.com/drugs/compound-sodium-lactate/compound-sodium-lactate.pdf
  11. S. H. Park, Modern Design of Experiments (Minyongsa, Korea, 1995), pp. 452-453
  12. D. Lafrance, L. C. Lands, and D. H. Burns, 'Measurement of lactate in whole human blood with near-infrared transmission spectroscopy,' Talanta 60, 635-641 (2003) https://doi.org/10.1016/S0039-9140(03)00042-0
  13. A. Sieg, R. H. Guy, and M. B. Delgado-Charro, 'Simultaneous extraction of urea and glucose by reverse iontophoresis in vivo,' Pharmaceutical Research 10, 1805-1810 (2004) https://doi.org/10.1023/B:PHAM.0000045233.54878.f6
  14. J. P. Bantle and W. Thomas, 'Glucose measurement in patients with diabetes mellitus with dermal interstitial fluid,' J. Lab. Clin. Med. 130, 436-441 (1997) https://doi.org/10.1016/S0022-2143(97)90044-5
  15. K. J. Jeon, I. D. Hwang, S. Hahn, and G. Yoon, 'Comparison between transmittance and reflectance measurements in glucose determination using near infrared spectroscopy,' Journal of Biomedical Optics 11, 014022-1~014022-7 (2006) https://doi.org/10.1117/1.2165572

Cited by

  1. Measurement of Glucose and Protein in Urine Using Absorption Spectroscopy Under the Influence of Other Substances vol.20, pp.6, 2009, https://doi.org/10.3807/KJOP.2009.20.6.346
  2. Infrared spectroscopic analysis of human interstitial fluid in vitro and in vivo using FT-IR spectroscopy and pulsed quantum cascade lasers (QCL): Establishing a new approach to non invasive glucose measurement vol.85, pp.1, 2012, https://doi.org/10.1016/j.saa.2011.09.007
  3. Dielectric properties of glucose in bulk aqueous solutions: Influence of electrode polarization and modeling vol.26, pp.5, 2011, https://doi.org/10.1016/j.bios.2010.10.009