Antibacterial effects of Mume Fructus Water Extract against Salmonella typhimurium in Murine Salmonellosis

Jung, Won-Chul;Cha, Chun-Nam;Lee, Hu-Jang

  • Received : 2009.08.27
  • Accepted : 2009.10.10
  • Published : 2009.10.31


The present study was undertaken to estimate the antibacterial effect of Mume Fructus water extract (MFWE) against murine salmonellosis. At MFWE concentrations ranging from 25 to 100 ${\mu}g/ml$, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, bacteria without MFWE had a tendency to proliferate up to 8 h after incubation. Oral administration of MFWE at the dose of 40 mg/ml showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of MFWE-treated mice was 80% at 12 days, while that of MFWE-untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that MFWE has potential as an effective of salmonellosis.


Mume Fructus water extract;antibacterial effect;salmonellosis;Salmonella typhimurium


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