Development of Biomimetic Scaffold for Tissue Engineering

조직공학을 위한 생체모사용 스캐폴드 개발

  • Park, Su-A (Nano-Mechanical Systems Research Division, Korea Institute of Machinery & Materials (KIMM)) ;
  • Lee, Jun-Hee (Nano-Mechanical Systems Research Division, Korea Institute of Machinery & Materials (KIMM)) ;
  • Kim, Wan-Doo (Nano-Mechanical Systems Research Division, Korea Institute of Machinery & Materials (KIMM))
  • 박수아 (한국기계연구원 나노융합기계연구본부) ;
  • 이준희 (한국기계연구원 나노융합기계연구본부) ;
  • 김완두 (한국기계연구원 나노융합기계연구본부)
  • Published : 2009.06.30


Tissue engineering is a research field for artificial substitutes to improve or replace biological functions. Scaffolds play a important role in tissue engineering. Scaffold porosity and pore size provide adequate space, nutrient transportation and cell penetration throughout the scaffold structure. Scaffold structure is directly related to fabrication methods. This review will introduce the current technique of 3D scaffold fabrication for tissue engineering. The conventional technique for scaffold fabrication includes salt leaching, gas foaming, fiber bonding, phase seperation, melt moulding, and freeze drying. These conventional scaffold fabrication has the limitations of cell penetration and interconnectivity. In this paper, we will present the solid freeform fabrication (SFF) such as stereolithography (SLA), selective laser sintering (SLS), and fused deposition modeling (FDM), and 3D printing (3DP).


  1. E. Sacholos and J. T. Czernuszka, 'Making tissue engineering scaffolds work. Review on the application of solid freeform fabrcation technology to the production of tissue engineering scaffolds', Euro. Cells Mater., 5, 29 (2003)
  2. W. E. Teo and S. Ramakrishna, 'A review on electrospinning design and nanofibre assemblies', Nanotechnology, 17, R89 (2006)
  3. S. A. Park, K. E. Park, H. Yoon, J. G. Son, T. J. Min, and G. H. Kim, 'Apparatus for preparing electrospun nanofibers: designing an electrospinning process for nanofiber fabrication', Polym. Inter., 56, 1361 (2007)
  4. S. J. Hollister, 'Porous scaffold design for tissue engineering', Nature Mater., 4, 518 (2005)
  5. X. Wang, Y. Yan, and R. Zhang, 'Raid prototyping as a tool for manufacturing bioartificial livers', TRENDS in Biotech., 25, 505 (2007)
  6. N.E. Fedorovich, J. Dewijn, A.J. Verbout, J. Alblas, and W. J. A. Dhert, 'Three-Dimensional Fiber Deposition of Cell-Laden, Viable, Patterned Constructs for Bone Tissue Printing', Tissue Eng., 14, 127 (2008)