Enhancement of the Antioxidant and Anticancer Activities of Berberis koreana Bark by Using a Low Temperature and High-Pressure Extraction Process

저온고압 추출공정을 이용한 매자나무 수피의 항산화 및 항암활성 증진

  • Jin, Ling (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ha, Ji-Hye (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Jeong, Myoung-Hoon (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Chung, Eul-Kwon (Myung Jin Farm Coperation) ;
  • Chung, Ae-Ran (Myung Jin Farm Coperation) ;
  • Kim, Jin-Chul (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ahn, Ju-Hee (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Hyeon-Yong (Research Institute of Bioscience and Biotechnology, Kangwon National University)
  • 김영 (강원대학교 BT 특성화학부대학) ;
  • 하지혜 (강원대학교 BT 특성화학부대학) ;
  • 정명훈 (강원대학교 BT 특성화학부대학) ;
  • 정을권 (명진농장) ;
  • 정애란 (명진농장) ;
  • 김진철 (강원대학교 BT 특성화학부대학) ;
  • 안주희 (강원대학교 BT 특성화학부대학) ;
  • 이현용 (강원대학교 생명공학연구소)
  • Published : 2009.06.30


This study was conducted to characterize the enhanced antioxidant and anticancer activities of Berberis koreana bark following a low temperature and high pressure extraction process. The results indicate that the B. koreana bark extracted as described showed a 93% increase in DPPH radical scavenging activity. Inhibition activity of xanthine oxidase was highest by this extraction process. In addition the growth of human lung cancer cells (A549), human stomach cancer cells (AGS), human breast cancer cells (MCF-7) and human liver cancer cells (Hep3B) were inhibited by 70.8%, 86.2%, 84.3% and 62.5% respectively. These data indicate that this low temperature and high pressure extraction technique results in the efficient extraction of bioactive compounds from rigid plant materials. This process could also be combined with other techniques to improve extraction yields and identify new biologically active substances from relatively hard plants.


Berberis koreana bark;low temperature and high-pressure extraction;antioxidant activity;anticancer activity


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