Antiinflammatory Effect of Aqueous Extract from Red Pepper on Lipopolysaccharide Induced Inflammatory Responses in Murine Macrophages

홍고추가루 수용성 추출물의 항염증 효과

  • Kwon, Hyuck-Se (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Shin, Hyun-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University) ;
  • Kwon, Sang-O (S&D Co., Ltd) ;
  • Yeo, Kyung-Mok (S&D Co., Ltd) ;
  • Kim, Sang-Moo (S&D Co., Ltd) ;
  • Kim, Bok-Nam (Dept. of Tourism and Food Service Cuisine, Hallym College) ;
  • Kim, Jin-Kyung (Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University)
  • 권혁세 (한림대학교 식의약품의 효능평가 및 기능성 소재개발센터) ;
  • 신현경 (한림대학교 식의약품의 효능평가 및 기능성 소재개발센터) ;
  • 권상오 ((주)에스엔디) ;
  • 여경목 ((주)에스엔디) ;
  • 김상무 ((주)에스엔디) ;
  • 김복남 (한림성심대학 관광외식조리과) ;
  • 김진경 (한림대학교 식의약품의 효능평가 및 기능성 소재개발센터)
  • Published : 2009.10.31


Inflammation is a pivotal component of a variety of diseases, such as atherosclerosis and tumour progression. Various naturally occurring phytochemicals exhibit antiinflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Red pepper is the most consumed species in Korea. However, the antiinflammatory effects of red pepper have not been characterized. Thus, the present study was designed to evaluate the effects of the aqueous extract from red pepper (RPAE) on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages. RPAE demonstrated strong antiinflammatory activity through its ability to reduce nitric oxide and prostaglandin $E_2$ production in the LPS-stimulated mouse macrophage cell, RAW264.7. It also inhibited the production of interleukin-6 (IL-6) on the LPS-stimulated RAW264.7 cells. Further study indicated that LPS-stimulated induction of inducible nitric oxide synthase and cyclooxygenase-2 was significantly inhibited by RPAE exposure (1,000 mg/mL) in RAW264.7 cells. Collectively, these data suggest that the use of RPAE may be a useful therapeutic approach to various inflammatory diseases.


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