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Modulation of Ethanol-Induced P450 Enzyme Activities and Antioxidants in Mice by Hordeum vulgare Extract

만성 알코올 급여 흰쥐에서 보리 추출물 섭취가 Cytochrome P450 효소 조절 및 항산화계에 미치는 영향

  • Lee, Yoo-Hyun (Dept. of Food Science and Nutrition, University of Suwon) ;
  • Lee, Jeong-Min (Dept of Medical Nutrition, Kyunghee University) ;
  • Im, Eun-Jeong (Dept of Food Service, Hanyang Women's College) ;
  • Jun, Woo-Jin (Dept. of Food and Nutrition, Chonnam National University) ;
  • Cho, Hong-Yon (Dept of Food and Biotechnology, Korea University)
  • Published : 2009.10.31

Abstract

The effects of methanol extract of barely (Hordeum vulgare) on alcohol-induced damages of liver were investigated in male ICR mice. Mice were divided into three groups, control, ethanol, and ethanol plus 0.15% of barley extract. After four weeks of ethanol feeding, ethanol group significantly increased the P450 content, CYP2E1 and CYP1A2 enzyme activities, whereas ethanol plus barely group markedly decreased to levels similar to control group. Catalase activity in ethanol group was significantly lower than that in control group; however, ethanol plus barely group stimulated catalase activity as well as SOD activity significantly. These results indicated that barely extract modulated P450 enzymes for ethanol-induced liver damage and might be useful in developing functional food for alcoholic liver damage.

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