Effect of Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate in human intrabony defects

성인 치조골 내 결손부에서 Silicon contained Coralline Hydroxyapatite와 Beta Tricalcium Phosphate 합성제재의 효과에 대한 임상적 고찰

  • Jang, Yong-Ju (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Yong-Tae (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Park, Jung-Chul (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chang-Sung (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
  • 장용주 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소) ;
  • 김용태 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소) ;
  • 박정철 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소) ;
  • 김창성 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직 재생 연구소)
  • Published : 2009.09.01

Abstract

Aim : The ultimate goal of periodontal treatment is regeneration of periodontium that have been lost due to inflammatory periodontal disease. Recently, Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate bone substitute have been introduced to achieve periodontal regeneration. The purpose of this study is to evaluate the effect of the Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate(BoneMedik-$DM^{(R)}$, Meta Biomed Co., Ltd. Oksan, Korea) on periodontal intrabony defects. Methods and materials : Clinical effects of Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate implantation in intrabony defects were evaluated 6 months after surgery in Sixty-one intrabony defects from Fourty-six patients with chronic periodontitis. Twenty-nine experimental defects in twenty-five patients received the Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate(test group), while Thirty-Three defects in twenty-one patients were treated with flap procedure only( control group). Comparative observation were done for preoperative and postoperative differences between control and experimental clinical parameters,-clinical attachment 10ss(CAL), probing depth(PD), bone probing depth(BPD), gingi val recession. Results : Postoperative improvements in CAL, PD, BPD were observed in both test and control groups(P<0.0l). However, the improvements in CAL, PD, BPD of the test group were significantly greater than control group. Conclusion : Healing of the both groups were uneventful during experimental periods. Use of Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate in a flap operation resulted in significantly greater improvements in CAL, PD, and BPD over flap operation alone. Silicon contained Coralline Hydroxyapatite and Beta Tricalcium Phosphate will be good bone substitute materials for treatment of intrabony defects.

References

  1. Stahl SS, Froum SJ, Kushner L. Periodontal healing following open debridement flap procedures. II. Histologic observations. J Periodontol 1982;53:15-21. https://doi.org/10.1902/jop.1982.53.1.15
  2. Nyman S, Lindhe J, Karring T, Rylander H. New attachment following surgical treatment of human periodontal disease. J Clin Periodontol 1982;9:290-296. https://doi.org/10.1111/j.1600-051X.1982.tb02095.x
  3. Lindhe J, Karring T, Lang N. Clinical periodontology and implant dentistry, fourth ed. Copenhagen:Munksgaard; 2003:656.
  4. Marx RE. Clinical application of bone biology to mandibular and maxillary reconstruction. Clin Plast Surg 1994;21:377-392.
  5. Dragoo MR, Sullivan HC. A clinical and histological evaluation of autogenous iliac bone grafts in humans. II. External root resorption. J Periodontol 1973;44:614-625. https://doi.org/10.1902/jop.1973.44.10.614
  6. Camelo M, Nevins ML, Lynch SE et al. Periodontal regeneration with an autogenous bone-Bio-Oss composite graft and a Bio-Gide membrane. Int J Periodontics Restorative Dent 2001;21:109-119.
  7. Mellonig JT. Human histologic evaluation of a bovinederived bone xenograft in the treatment of periodontal osseous defects. Int J Periodontics Restorative Dent 2000;20:19-29.
  8. Froum SJ, Kushner L, Scopp IW, Stahl SS. Human clinical and histologic responses to Durapatite implants in intraosseous lesions. Case reports. J Periodontol 1982;53:719-725. https://doi.org/10.1902/jop.1982.53.12.719
  9. Nery EB, LeGeros RZ, Lynch KL, Lee K. Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects. J Periodontol 1992;63:729-735. https://doi.org/10.1902/jop.1992.63.9.729
  10. Jensen SS, Yeo A, Dard M et al. Evaluation of a novel biphasic calcium phosphate in standardized bone defects:a histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2007;18:752-760. https://doi.org/10.1111/j.1600-0501.2007.01417.x
  11. Park JS, Suh JJ, Choi SH et al. Effects of pretreatment clinical parameters on bioactive glass implantation in intrabony periodontal defects. J Periodontol 2001;72:730- 740. https://doi.org/10.1902/jop.2001.72.6.730
  12. Mellonig JT. Decalcified freeze-dried bone allograft as an implant material in human periodontal defects. Int J Periodontics Restorative Dent 1984;4:40-55.
  13. Pihlstrom BL, Ortiz-Campos C, McHugh RB. A randomized four-years study of periodontal therapy. J Periodontol 1981;52:227-242. https://doi.org/10.1902/jop.1981.52.5.227
  14. Cho KS, Choi SH, Han KH et al. Alveolar bone formation at dental implant dehiscence defects following guided bone regeneration and xenogeneic freeze-dried demineralized bone matrix. Clin Oral Implants Res 1998;9:419-428. https://doi.org/10.1034/j.1600-0501.1996.090607.x
  15. Yun JH, Hwang SJ, Kim CS et al. The correlation between the bone probing, radiographic and histometric measurements of bone level after regenerative surgery. J Periodontal Res 2005;40:453-460. https://doi.org/10.1111/j.1600-0765.2005.00825.x
  16. Kim CK, Chai JK, Cho KS, Choi SH. Effect of calcium sulphate on the healing of periodontal intrabony defects. Int Dent J 1998;48:330-337. https://doi.org/10.1111/j.1875-595X.1998.tb00725.x
  17. Kim CK, Choi EJ, Cho KS, Chai JK, Wikesjo UM. Periodontal repair in intrabony defects treated with a calcium carbonate implant and guided tissue regeneration. J Periodontol 1996;67:1301-1306. https://doi.org/10.1902/jop.1996.67.12.1301
  18. Galgut PN, Waite IM, Brookshaw JD, Kingston CP. A 4- year controlled clinical study into the use of a ceramic hydroxylapatite implant material for the treatment of periodontal bone defects. J Clin Periodontol 1992;19:570- 577. https://doi.org/10.1111/j.1600-051X.1992.tb00685.x
  19. Ellinger RF, Nery EB, Lynch KL. Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics:a case report. Int J Periodontics Restorative Dent 1986;6:22-33.
  20. Renvert S, Nilveus R, Egelberg J. Healing after treatment of periodontal intraosseous defects. V. Effect of root planing versus flap surgery. J Clin Periodontol 1985;12:619-629. https://doi.org/10.1111/j.1600-051X.1985.tb00933.x
  21. Yukna RA, Mayer ET, Amos SM. 5-year evaluation of durapatite ceramic alloplastic implants in periodontal osseous defects. J Periodontol 1989;60:544-551. https://doi.org/10.1902/jop.1989.60.10.544
  22. Jensen SS, Broggini N, Hjorting-Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2006;17:237-243. https://doi.org/10.1111/j.1600-0501.2005.01257.x
  23. Becker W, Becker BE, Caffesse R. A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128-1133. https://doi.org/10.1902/jop.1994.65.12.1128
  24. Renvert S, Garrett S, Nilveus R, Chamberlain AD,Egelberg J. Healing after treatment of periodontal intraosseous defects. VI. Factors influencing the healing response. J Clin Periodontol 1985;12:707-715. https://doi.org/10.1111/j.1600-051X.1985.tb01396.x
  25. Trombelli L, Kim CK, Zimmerman GJ, Wikesjo UM. Retrospective analysis of factors related to clinical outcome of guided tissue regeneration procedures in intrabony defects. J Clin Periodontol 1997;24:366-371. https://doi.org/10.1111/j.1600-051X.1997.tb00199.x
  26. Westfelt E, Bragd L, Socransky SS et al. Improved periodontal conditions following therapy. J Clin Periodontol 1985;12:283-293. https://doi.org/10.1111/j.1600-051X.1985.tb02294.x
  27. Becker W, Lynch SE, Lekholm U et al. A comparison of ePTFE membranes alone or in combination with platelet-derived growth factors and insulin-like growth factor-I or demineralized freeze-dried bone in promoting bone formation around immediate extraction socket implants. J Periodontol 1992;63:929-940. https://doi.org/10.1902/jop.1992.63.11.929
  28. Reddy MS, Jeffcoat MK. Methods of assessing periodontal regeneration. Periodontol 2000 1999;19:87- 103. https://doi.org/10.1111/j.1600-0757.1999.tb00149.x
  29. Becker W, Clokie C, Sennerby L, Urist MR, Becker BE. Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets:case reports. J Periodontol 1998;69:414-421. https://doi.org/10.1902/jop.1998.69.4.414
  30. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol 2003;8:227-265. https://doi.org/10.1902/annals.2003.8.1.227
  31. Skowronski J. Tactics in the treatment of fractures of the distal epiphysis of the radial bone. Ortop Traumatol Rehabil 2003;5:70-79.
  32. Wilson J, Low SB. Bioactive ceramics for periodontal treatment:comparative studies in the Patus monkey. J Appl Biomater 1992;3:123-129. https://doi.org/10.1002/jab.770030208
  33. Kim CK, Chai JK, Cho KS et al. Periodontal repair in intrabony defects treated with a calcium sulfate implant and calcium sulfate barrier. J Periodontol 1998;69:1317- 1324. https://doi.org/10.1902/jop.1998.69.12.1317
  34. Toback GA, Brunsvold MA, Nummikoski PV et al. The accuracy of radiographic methods in assessing the outcome of periodontal regenerative therapy. J Periodontol 1999;70:1479-1489. https://doi.org/10.1902/jop.1999.70.12.1479
  35. Paolantonio M, Scarano A, Di Placido G et al. Periodontal healing in humans using anorganic bovine bone and bovine peritoneum-derived collagen membrane:a clinical and histologic case report. Int J Periodontics Restorative Dent 2001;21:505-515.
  36. Yukna RA. Clinical evaluation of coralline calcium carbonate as a bone replacement graft material in human periodontal osseous defects. J Periodontol 1994;65:177-185. https://doi.org/10.1902/jop.1994.65.2.177
  37. Roberts WW, Martin JR. Effects of lesions in central thermosensitive areas on thermoregulatory responses in rat. Physiol Behav 1977;19:503-511. https://doi.org/10.1016/0031-9384(77)90226-8
  38. Wilson J, Merwin GE. Biomaterials for facial bone augmentation:comparative studies. J Biomed Mater Res 1988;22:159-177.
  39. Skrtic D, Antonucci JM, Eanes ED, Brunworth RT. Silicaand zirconia-hybridized amorphous calcium phosphate: effect on transformation to hydroxyapatite. J Biomed Mater Res 2002;59:597-604. https://doi.org/10.1002/jbm.10017
  40. Kim CK, Kim HY, Chai JK et al. Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs. J Periodontol 1998;69:982-988. https://doi.org/10.1902/jop.1998.69.9.982
  41. Kim TS, Benn DK, Eickholz P. Accuracy of computerassisted radiographic measurement of interproximal bone loss in vertical bone defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:379-387. https://doi.org/10.1067/moe.2002.126909
  42. Bowers GM, Vargo JW, Levy B, Emerson JR, Bergquist JJ. Histologic observations following the placement of tricalcium phosphate implants in human intrabony defects. J Periodontol 1986;57:286-287. https://doi.org/10.1902/jop.1986.57.5.286
  43. Sogal A, Tofe AJ. Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999;70:1053-1063. https://doi.org/10.1902/jop.1999.70.9.1053
  44. Kim CK, Cho KS, Choi SH, Prewett A, Wikesjo UM. Periodontal repair in dogs:effect of allogenic freezedried demineralized bone matrix implants on alveolar bone and cementum regeneration. J Periodontol 1998;69:26-33. https://doi.org/10.1902/jop.1998.69.1.26
  45. Nevins ML, Camelo M, Lynch SE, Schenk RK, Nevins M. Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen:a human histologic report. Int J Periodontics Restorative Dent 2003;23:9-17.
  46. Lynch SE. Methods for evaluation of regenerative procedures. J Periodontol 1992;63:1085-1092. https://doi.org/10.1902/jop.1992.63.12s.1085
  47. Yukna RA. Synthetic bone grafts in periodontics. Periodontol 2000 1993;1:92-99. https://doi.org/10.1111/j.1600-0757.1993.tb00210.x
  48. Libin BM, Ward HL, Fishman L. Decalcified, lyophilized bone allografts for use in human periodontal defects. J Periodontol 1975;46:51-56. https://doi.org/10.1902/jop.1975.46.1.51
  49. Getter L, Bhaskar SN, Cutright DE et al. Three biodegradable calcium phosphate slurry implants in bone. J Oral Surg 1972;30:263-268.
  50. Schallhorn RG, Hiatt WH. Human allografts of iliac cancellous bone and marrow in periodontal osseous defects. II. Clinical observations. J Periodontol 1972;43:67-81. https://doi.org/10.1902/jop.1972.43.2.67
  51. Machtei EE, Dunford RG, Norderyd OM, Zambon JJ, Genco RJ. Guided tissue regeneration and anti-infective therapy in the treatment of class II furcation defects. J Periodontol 1993;64:968-973. https://doi.org/10.1902/jop.1993.64.10.968
  52. Gould TR, Melcher AH, Brunette DM. Location of progenitor cells in periodontal ligament of mouse molar stimulated by wounding. Anat Rec 1977;188:133-141. https://doi.org/10.1002/ar.1091880202
  53. Yukna RA, Krauser JT, Callan DP et al. Thirty-six month follow-up of 25 patients treated with combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell-binding peptide (P-15) bone replacement grafts in human infrabony defects. I. Clinical findings. J Periodontol 2002;73:123-128. https://doi.org/10.1902/jop.2002.73.1.123