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Biological Activities of Solvent Extracts from Leaves of Aceriphyllum rossii

돌단풍 잎 용매추출물의 생리활성

  • Lim, Sang-Hyun (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Kim, Hee-Yeon (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Park, Min-Hee (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Park, Yu-Hwa (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Ham, Hun-Ju (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Lee, Ki-Yun (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Kim, Kyung-Hee (Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment Services) ;
  • Park, Dong-Sik (National Academy of Agricultural Science) ;
  • Kim, Song-Mun (Dept. of Biological Environment, Kangwon National University)
  • 임상현 (강원도농업기술원 농산물이용시험장) ;
  • 김희연 (강원도농업기술원 농산물이용시험장) ;
  • 박민희 (강원도농업기술원 농산물이용시험장) ;
  • 박유화 (강원도농업기술원 농산물이용시험장) ;
  • 함헌주 (강원도농업기술원 농산물이용시험장) ;
  • 이기연 (강원도농업기술원 농산물이용시험장) ;
  • 김경희 (강원도농업기술원 농산물이용시험장) ;
  • 박동식 (농촌진흥청 국립농업과학원 한식세계화연구단 기능성식품과) ;
  • 김성문 (강원대학교 바이오자원환경학과)
  • Received : 2010.11.05
  • Accepted : 2010.12.06
  • Published : 2010.12.31

Abstract

In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and $62.14{\mu}g$/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 mg/mL, respectively. In the anti-diabetic activity, $IC_{50}$ of $\alpha$-glucosidase inhibitory activity was 5.62 and $425.63{\mu}g$/mL by EEAR and WEAR. $IC_{50}$ of $\alpha$-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over $10,000{\mu}g$/mL, respectively. In the anti-obesity, all lipase inhibitory activity ($IC_{50}$) of EEAR and WEAR was up $10,000{\mu}g$/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.

Acknowledgement

Supported by : 농촌진흥청

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