Evaluation of Interaction and Safety in Administering Herb-medicine with Warfarin

한약과 와파린 병용의 상호작용과 안전성에 대한 연구

  • Kwon, Dong-Hyun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University) ;
  • Kim, Ho-Jun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University) ;
  • Lee, Myeong-Jong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University) ;
  • Song, Mi-Young (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Guk University)
  • 권동현 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 이명종 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 송미영 (동국대학교 한의과대학 한방재활의학과교실)
  • Received : 2010.03.27
  • Accepted : 2010.04.14
  • Published : 2010.04.30


Objectives : The purpose of this study is to investigate interaction and safety in administering herb-medicine with warfarin. Methods : For this study, we selected 19 patients who have been taking warfarin, from the ones that have been transferred from western hospital to oriental hospital. During their stay in the oriental hospital, we gave herb-medicine in addition to warfarin. Then we gathered informations and data on sex, age, main indications, and International Normalized Ratio(INR) values of selected patients through Electronic Medical Records(EMR) of Dong-Guk university hospital. Accordingly, we compiled all of the above data for a period of 10 days prior and 10 days post admission(western hospital period and oriental hospital period, respectively). Results and Conclusions : The statistical analysis of the data have revealed that there was no significant change of INR values after giving herb-medicine with warfarin(p=0.586). The result shows that administration of herb-medicine with warfarin is safe and has little drug interaction. However, this study was carried out on small sample size and the interaction with other drugs and various kinds of herb-medicine was not considered. Although we attained a restrictive result from this study, we are able to suggest the safety about co-administration of herb-medicine and warfarin.


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